OBJECTIVE: Rheumatoid arthritis (RA) is a disease with unknown etiology but it is probably multifactorial. RA susceptibility is related to genetic, hormonal, immunologic, and environmental factors. Mannose-binding lectin (MBL) is an important protein of the human innate immune system, encoded by the MBL2 gene. Polymorphisms in MBL2 were associated with several diseases, and may be an important factor in RA susceptibility. We analyzed 3 MBL2 gene polymorphisms in 322 Brazilian patients with RA and 345 ethnically matched healthy controls. METHODS: MBL2 gene variants were analyzed through polymerase chain reaction sequencing. RESULTS: Considering MBL2 B, C, and D alleles separately, a significant difference in both genotypic and allelic frequencies, particularly concerning frequency of the C allele, was observed comparing European-derived and African-derived individuals (European-derived patients 0.022 vs African-derived patients 0.205; European-derived controls 0.029 vs African-derived controls 0.144; both p < 0.001). We also analyzed MBL2 genotype in relation to extraarticular manifestations. Considering MBL2 variants together, we found an increased frequency of the OO genotype among patients with rheumatoid nodules (p = 0.031), although this association lost significance after Bonferroni correction. CONCLUSION: Our findings suggest an association of MBL2 genotypes with some clinical manifestations of RA, but more studies are needed to clarify the actual role of MBL in RA.
OBJECTIVE:Rheumatoid arthritis (RA) is a disease with unknown etiology but it is probably multifactorial. RA susceptibility is related to genetic, hormonal, immunologic, and environmental factors. Mannose-binding lectin (MBL) is an important protein of the human innate immune system, encoded by the MBL2 gene. Polymorphisms in MBL2 were associated with several diseases, and may be an important factor in RA susceptibility. We analyzed 3 MBL2 gene polymorphisms in 322 Brazilian patients with RA and 345 ethnically matched healthy controls. METHODS:MBL2 gene variants were analyzed through polymerase chain reaction sequencing. RESULTS: Considering MBL2 B, C, and D alleles separately, a significant difference in both genotypic and allelic frequencies, particularly concerning frequency of the C allele, was observed comparing European-derived and African-derived individuals (European-derived patients 0.022 vs African-derived patients 0.205; European-derived controls 0.029 vs African-derived controls 0.144; both p < 0.001). We also analyzed MBL2 genotype in relation to extraarticular manifestations. Considering MBL2 variants together, we found an increased frequency of the OO genotype among patients with rheumatoid nodules (p = 0.031), although this association lost significance after Bonferroni correction. CONCLUSION: Our findings suggest an association of MBL2 genotypes with some clinical manifestations of RA, but more studies are needed to clarify the actual role of MBL in RA.
Authors: Isabela Goeldner; Thelma L Skare; Shirley R Utiyama; Renato M Nisihara; Hoang van Tong; Iara J T Messias-Reason; Thirumalaisamy P Velavan Journal: PLoS One Date: 2014-04-21 Impact factor: 3.240
Authors: Isabela Goeldner; Thelma Skare; Angelica B W Boldt; Flavia R Nass; Iara J Messias-Reason; Shirley R Utiyama Journal: PLoS One Date: 2014-03-14 Impact factor: 3.240
Authors: Pedro Henrique de Souza Ferreira Bringel; Gabriela Fernandes Oliveira Marques; Maria Gleiciane de Queiroz Martins; Mayara Torquato Lima da Silva; Clareane Avelino Simplício Nobre; Kyria Santiago do Nascimento; Benildo Sousa Cavada; Rondinelle Ribeiro Castro; Ana Maria Sampaio Assreuy Journal: Inflammation Date: 2020-08 Impact factor: 4.657
Authors: Justin S Antony; Olusola Ojurongbe; Hoang van Tong; Eman Abou Ouf; Thomas Engleitner; Akeem A Akindele; Olawumi R Sina-Agbaje; Adegboyega O Adeyeba; Peter G Kremsner; Thirumalaisamy P Velavan Journal: J Infect Dis Date: 2013-02-28 Impact factor: 5.226