Literature DB >> 22001684

Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients.

Frisullo Giovanni1, Plantone Domenico, Marti Alessandro, Iorio Raffaele, Nociti Viviana, Patanella Agata Katia, Batocchi Anna Paola.   

Abstract

Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22001684     DOI： 10.1016/j.jneuroim.2011.09.002

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  6 in total

1.  HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence.

Authors:  Tatiana Koudriavtseva; Domenico Plantone; Chiara Mandoj; Diana Giannarelli; Alessandra Latini; Manuela Colafigli; Elisabetta Trento; Paola Cordiali-Fei; Fulvia Pimpinelli
Journal:  J Neurovirol       Date:  2016-07-18       Impact factor: 2.643

2.  Dimethyl fumarate may still have a role in progressive multiple sclerosis.

Authors:  Domenico Plantone; Floriana De Angelis; Anisha Doshi; Jeremy Chataway
Journal:  Ther Adv Neurol Disord       Date:  2016-04-06       Impact factor: 6.570

Review 3.  Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal Models.

Authors:  Taryn E Mockus; Ashley Munie; Jeffrey R Atkinson; Benjamin M Segal
Journal:  J Immunol       Date:  2021-01-01       Impact factor: 5.422

4.  Effectiveness and safety of dimethyl fumarate in progressive multiple sclerosis.

Authors:  Vanessa F Moreira Ferreira; Yanqing Liu; Brian C Healy; James M Stankiewicz
Journal:  Mult Scler J Exp Transl Clin       Date:  2021-04-29

5.  Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo.

Authors:  Yang Lili; Wei Yi; Yang Ji; Sun Yue; Shi Weimin; Li Ming
Journal:  PLoS One       Date:  2012-05-23       Impact factor: 3.240

Review 6.  CD8(+) T-Cells as Immune Regulators of Multiple Sclerosis.

Authors:  Sushmita Sinha; Alexander W Boyden; Farah R Itani; Michael P Crawford; Nitin J Karandikar
Journal:  Front Immunol       Date:  2015-12-10       Impact factor: 7.561
  6 in total

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