| Literature DB >> 22001678 |
Yuxin Li1, Christiaan Schiepers, Ralph Lake, Simin Dadparvar, Gholam R Berenji.
Abstract
(18)F labeled sodium fluoride is a positron-emitting, bone seeking agent with more favorable skeletal kinetics than conventional phosphate and diphosphonate compounds. With the expanding clinical usage of PET/CT, there is renewed interest in using (18)F-fluoride PET/CT for imaging bone diseases. Growing evidence indicates that (18)F fluoride PET/CT offers increased sensitivity, specificity, and diagnostic accuracy in evaluating metastatic bone disease compared to (99m)Tc based bone scintigraphy. National Oncologic PET Registry (NOPR) has expanded coverage for (18)F sodium fluoride PET scans since February 2011 for the evaluation of osseous metastatic disease. In this article, we reviewed the pharmacological characteristics of sodium fluoride, as well as the clinical utility of PET/CT using (18)F-fluoride in both benign and malignant bone disorders. Published by Elsevier Inc.Entities:
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Year: 2011 PMID： 22001678 DOI： 10.1016/j.bone.2011.09.053
Source DB: PubMed Journal: Bone ISSN： 1873-2763 Impact factor: 4.398