Literature DB >> 22001163

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas.

Benjamin M Ellingson1, Timothy F Cloughesy, Whitney B Pope, Taryar M Zaw, Heidi Phillips, Shadi Lalezari, Phioanh L Nghiemphu, Hassana Ibrahim, Kourosh M Naeini, Robert J Harris, Albert Lai.   

Abstract

Promoter methylation of O6-methylguanine DNA methyltransferase (MGMT) is associated with a favorable prognosis in glioblastoma multiforme (GBM) and has been hypothesized to occur early in tumor transformation of glial cells. Thus, a possible link exists between the site of malignant transformation and MGMT promoter methylation status. Using the Analysis of Differential Involvement (ADIFFI) statistical mapping technique in a total of 358 patients with GBM, we demonstrate that human de novo GBMs occur in a high frequency contiguous with the posterior subventricular zone (SVZ); MGMT promoter methylated GBMs are lateralized to the left hemisphere, while MGMT unmethylated GBMs are lateralized to the right hemisphere; and tumors near the left temporal lobe have a significantly longer overall survival compared with tumors occurring elsewhere, independent of treatment or MGMT methylation status.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22001163     DOI： 10.1016/j.neuroimage.2011.09.076

Source DB:  PubMed          Journal:  Neuroimage        ISSN： 1053-8119            Impact factor:   6.556


  60 in total

1.  Mono-exponential, diffusion kurtosis and stretched exponential diffusion MR imaging response to chemoradiation in newly diagnosed glioblastoma.

Authors:  Ararat Chakhoyan; Davis C Woodworth; Robert J Harris; Albert Lai; Phioanh L Nghiemphu; Linda M Liau; Whitney B Pope; Timothy F Cloughesy; Benjamin M Ellingson
Journal:  J Neurooncol       Date:  2018-05-31       Impact factor: 4.130

Review 2.  Radiogenomics and imaging phenotypes in glioblastoma: novel observations and correlation with molecular characteristics.

Authors:  Benjamin M Ellingson
Journal:  Curr Neurol Neurosci Rep       Date:  2015-01       Impact factor: 5.081

3.  Different spatial distributions of brain metastases from lung cancer by histological subtype and mutation status of epidermal growth factor receptor.

Authors:  Koji Takano; Manabu Kinoshita; Masatoshi Takagaki; Mio Sakai; Souichirou Tateishi; Takamune Achiha; Ryuichi Hirayama; Kazumi Nishino; Junji Uchida; Toru Kumagai; Jiro Okami; Atsushi Kawaguchi; Naoya Hashimoto; Katsuyuki Nakanishi; Fumio Imamura; Masahiko Higashiyama; Toshiki Yoshimine
Journal:  Neuro Oncol       Date:  2015-10-31       Impact factor: 12.300

Review 4.  Conventional and advanced imaging throughout the cycle of care of gliomas.

Authors:  Gilles Reuter; Martin Moïse; Wolfgang Roll; Didier Martin; Arnaud Lombard; Félix Scholtes; Walter Stummer; Eric Suero Molina
Journal:  Neurosurg Rev       Date:  2021-01-07       Impact factor: 3.042

5.  Noninvasive IDH1 mutation estimation based on a quantitative radiomics approach for grade II glioma.

Authors:  Jinhua Yu; Zhifeng Shi; Yuxi Lian; Zeju Li; Tongtong Liu; Yuan Gao; Yuanyuan Wang; Liang Chen; Ying Mao
Journal:  Eur Radiol       Date:  2016-12-21       Impact factor: 5.315

6.  Regional specificity of 1p/19q co-deletion combined with radiological features for predicting the survival outcomes of anaplastic oligodendroglial tumor patients.

Authors:  Kai Wang; Yinyan Wang; Xing Fan; Yanong Li; Xing Liu; Jiangfei Wang; Lin Ai; Jianping Dai; Tao Jiang
Journal:  J Neurooncol       Date:  2017-12-11       Impact factor: 4.130

7.  Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome.

Authors:  Shadi Lalezari; Arthur P Chou; Anh Tran; Orestes E Solis; Negar Khanlou; Weidong Chen; Sichen Li; Jose A Carrillo; Reshmi Chowdhury; Julia Selfridge; Desiree E Sanchez; Ryan W Wilson; Mira Zurayk; Jonathan Lalezari; Jerry J Lou; Laurel Ormiston; Karen Ancheta; Robert Hanna; Paul Miller; David Piccioni; Benjamin M Ellingson; Colin Buchanan; Paul S Mischel; Phioanh L Nghiemphu; Richard Green; He-Jing Wang; Whitney B Pope; Linda M Liau; Robert M Elashoff; Timothy F Cloughesy; William H Yong; Albert Lai
Journal:  Neuro Oncol       Date:  2013-01-17       Impact factor: 12.300

8.  Methylation-specific multiplex ligation-dependent probe amplification identifies promoter methylation events associated with survival in glioblastoma.

Authors:  K L Rankeillor; D A Cairns; C Loughrey; S C Short; P Chumas; A Ismail; A Chakrabarty; S E Lawler; P Roberts
Journal:  J Neurooncol       Date:  2014-02-20       Impact factor: 4.130

9.  Tumor location and patient age predict biological signatures of high-grade gliomas.

Authors:  Roberto Altieri; Francesco Zenga; Alessandro Ducati; Antonio Melcarne; Fabio Cofano; Marco Mammi; Giuseppe Di Perna; Riccardo Savastano; Diego Garbossa
Journal:  Neurosurg Rev       Date:  2017-08-31       Impact factor: 3.042

10.  Anatomical specificity of O6-methylguanine DNA methyltransferase protein expression in glioblastomas.

Authors:  Yinyan Wang; Xing Fan; Chuanbao Zhang; Tan Zhang; Xiaoxia Peng; Shaowu Li; Lei Wang; Jun Ma; Tao Jiang
Journal:  J Neurooncol       Date:  2014-07-17       Impact factor: 4.130
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.