| Literature DB >> 21999934 |
Wen Zeng1, Rong Wan, Yuehuan Zheng, Shree Ram Singh, Yiyong Wei.
Abstract
Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors. The hypoxia inducible factors (HIFs) are the key mediators of the cellular response to hypoxia. In this review, we focused on the role of HIFs on bone tumor formation. Further, we also emphasized how hypoxia, stem cells, and its niches regulate the bone tumorigenesis. Published by Elsevier Ireland Ltd.Entities:
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Year: 2011 PMID: 21999934 PMCID: PMC3215823 DOI: 10.1016/j.canlet.2011.09.023
Source DB: PubMed Journal: Cancer Lett ISSN: 0304-3835 Impact factor: 8.679