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5 in total

Review 1. Targeting the Hedgehog pathway in cancer.

Authors: Lee L Rubin; Frederic J de Sauvage
Journal: Nat Rev Drug Discov Date: 2006-12 Impact factor: 84.694

2. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

Authors: James K Chen; Jussi Taipale; Michael K Cooper; Philip A Beachy
Journal: Genes Dev Date: 2002-11-01 Impact factor: 11.361

3. Teratogen-mediated inhibition of target tissue response to Shh signaling.

Authors: M K Cooper; J A Porter; K E Young; P A Beachy
Journal: Science Date: 1998-06-05 Impact factor: 47.728

4. Small molecule modulation of Smoothened activity.

Authors: James K Chen; Jussi Taipale; Keith E Young; Tapan Maiti; Philip A Beachy
Journal: Proc Natl Acad Sci U S A Date: 2002-10-21 Impact factor: 11.205

5. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Authors: J Taipale; J K Chen; M K Cooper; B Wang; R K Mann; L Milenkovic; M P Scott; P A Beachy
Journal: Nature Date: 2000-08-31 Impact factor: 49.962

5 in total

1 in total

Review 1. Diagnosing the decline in pharmaceutical R&D efficiency.

Authors: Jack W Scannell; Alex Blanckley; Helen Boldon; Brian Warrington
Journal: Nat Rev Drug Discov Date: 2012-03-01 Impact factor: 84.694

1 in total