BACKGROUND: The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). METHODS: We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance. RESULTS: Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors. CONCLUSIONS: To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.
BACKGROUND: The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). METHODS: We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance. RESULTS:Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors. CONCLUSIONS: To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.
Authors: J T Powell; A R Brady; L C Brown; F G R Fowkes; R M Greenhalgh; C V Ruckley; S G Thompson Journal: N Engl J Med Date: 2002-05-09 Impact factor: 91.245
Authors: Frank A Lederle; Samuel E Wilson; Gary R Johnson; Donovan B Reinke; Fred N Littooy; Charles W Acher; David J Ballard; Louis M Messina; Ian L Gordon; Edmund P Chute; William C Krupski; Steven J Busuttil; Gary W Barone; Steven Sparks; Linda M Graham; Joseph H Rapp; Michel S Makaroun; Gregory L Moneta; Robert A Cambria; Raymond G Makhoul; Darwin Eton; Howard J Ansel; Julie A Freischlag; Dennis Bandyk Journal: N Engl J Med Date: 2002-05-09 Impact factor: 91.245
Authors: Francis J Miller; William J Sharp; Xiang Fang; Larry W Oberley; Terry D Oberley; Neal L Weintraub Journal: Arterioscler Thromb Vasc Biol Date: 2002-04-01 Impact factor: 8.311
Authors: K Jamrozik; P E Norman; C A Spencer; R W Parsons; R Tuohy; M M Lawrence-Brown; J A Dickinson Journal: Med J Aust Date: 2000-10-02 Impact factor: 7.738
Authors: O M B McBride; N V Joshi; J M J Robson; T J MacGillivray; C D Gray; A M Fletcher; M R Dweck; E J R van Beek; J H F Rudd; D E Newby; S I Semple Journal: Eur J Vasc Endovasc Surg Date: 2016-02-23 Impact factor: 7.069