BACKGROUND: Infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are associated with increased therapeutic failure and mortality. Our laboratory recognized several strains producing KPC, most of which originated from transplantation ward patients. MATERIALS AND METHODS: All strains of K pneumoniae resistant to at least 1 carbapenem isolated in 2010 were examined for KPC production by disc diffusion and then verified by molecular methods. RESULTS: All positive strains originated from 7 patients. Six of them were from transplantation wards. None of the KPC-producing strains was isolated from the patient's blood. CONCLUSIONS: A quick, accurate diagnosis of KPC-producing strains enabled immediate isolation of carriers or infected persons. Isolation prevented spread of dangerous strains among immunocompromised patients and reduced the possibility of serious infections.
BACKGROUND:Infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are associated with increased therapeutic failure and mortality. Our laboratory recognized several strains producing KPC, most of which originated from transplantation ward patients. MATERIALS AND METHODS: All strains of K pneumoniae resistant to at least 1 carbapenem isolated in 2010 were examined for KPC production by disc diffusion and then verified by molecular methods. RESULTS: All positive strains originated from 7 patients. Six of them were from transplantation wards. None of the KPC-producing strains was isolated from the patient's blood. CONCLUSIONS: A quick, accurate diagnosis of KPC-producing strains enabled immediate isolation of carriers or infected persons. Isolation prevented spread of dangerous strains among immunocompromised patients and reduced the possibility of serious infections.
Authors: José Ramos-Vivas; Itziar Chapartegui-González; Marta Fernández-Martínez; Claudia González-Rico; Jesús Fortún; Rosa Escudero; Francesc Marco; Laura Linares; Miguel Montejo; Maitane Aranzamendi; Patricia Muñoz; Maricela Valerio; Jose María Aguado; Elena Resino; Irene Gracia Ahufinger; Aurora Paz Vega; Luis Martínez-Martínez; María Carmen Fariñas Journal: Sci Rep Date: 2019-06-20 Impact factor: 4.379