| Literature DB >> 21995420 |
Lili X Peng, Lei Yu, Stephen B Howell, David A Gough.
Abstract
The effects of paclitaxel (PTX) loading fraction and spatial PTX arrangement on poly(γ-glutamyl-glutamate) paclitaxel (PGG-PTX) aggregation were explored using coarse-grained molecular dynamics. Results show that the PTX loading fraction does not significantly impact aggregation, and the spatial PTX arrangement only affects aggregation at more concentrated PTX arrangements. Overall, the f(PTX) = 0.37 'ends' and f(PTX) = 0.18 'even' PGG-PTX systems exhibit the highest aggregation and the 'middle' and 'side' systems the lowest.Entities:
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Year: 2011 PMID： 21995420 DOI： 10.1021/ci200214m
Source DB: PubMed Journal: J Chem Inf Model ISSN： 1549-9596 Impact factor: 4.956