| Literature DB >> 21994111 |
Donald R Shaffer1, Andrea M Sheehan, Zhongzhen Yi, Cheryl C Rodgers, Catherine M Bollard, Malcolm K Brenner, Cliona M Rooney, Helen E Heslop, Stephen Gottschalk.
Abstract
Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma.Entities:
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Year: 2011 PMID: 21994111 PMCID: PMC3258475 DOI: 10.1002/pbc.23352
Source DB: PubMed Journal: Pediatr Blood Cancer ISSN: 1545-5009 Impact factor: 3.167