Literature DB >> 21993672

The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging.

Marijke W Maijenburg1, Marion Kleijer, Kim Vermeul, Erik P J Mul, Floris P J van Alphen, C Ellen van der Schoot, Carlijn Voermans.   

Abstract

Life-long hematopoiesis depends on the support of mesenchymal stromal cells within the bone marrow. Therefore, changes in the hematopoietic compartment that occur during development and aging probably correlate with variation in the composition of the stromal cell microenvironment. Mesenchymal stromal cells are a heterogeneous cell population and various subtypes may have different functions. In accordance with others, we show that CD271 and CD146 define distinct colony-forming-unit-fibroblast containing mesenchymal stromal cell subpopulations. In addition, analysis of 86 bone marrow samples revealed that the distribution of CD271(bright)CD146(-) and CD271(bright)CD146(+) subsets correlates with donor age. The main subset in adults was CD271(bright)CD146(-), whereas the CD271(bright)CD146(+) population was dominant in pediatric and fetal bone marrow. A third subpopulation of CD271(-)CD146(+) cells contained colony-forming-unit-fibroblasts in fetal samples only. These changes in composition of the mesenchymal stromal cell compartment during development and aging suggest a dynamic system, in which these subpopulations may have different functions.

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Mesh：

Year:  2011        PMID： 21993672      PMCID： PMC3269474          DOI： 10.3324/haematol.2011.047753

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  19 in total

1.  Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1.

Authors:  Venkata Lokesh Battula; Sabrina Treml; Petra M Bareiss; Friederike Gieseke; Helene Roelofs; Peter de Zwart; Ingo Müller; Bernhard Schewe; Thomas Skutella; Willem E Fibbe; Lothar Kanz; Hans-Jörg Bühring
Journal:  Haematologica       Date:  2008-12-09       Impact factor: 9.941

2.  Cell cycle and tissue of origin contribute to the migratory behaviour of human fetal and adult mesenchymal stromal cells.

Authors:  Marijke W Maijenburg; Willy A Noort; Marion Kleijer; Charlotte J A Kompier; Kees Weijer; Jaap D van Buul; C Ellen van der Schoot; Carlijn Voermans
Journal:  Br J Haematol       Date:  2009-10-22       Impact factor: 6.998

3.  CD146 expression on primary nonhematopoietic bone marrow stem cells is correlated with in situ localization.

Authors:  Ariane Tormin; Ou Li; Jan Claas Brune; Stuart Walsh; Birgit Schütz; Mats Ehinger; Nicholas Ditzel; Moustapha Kassem; Stefan Scheding
Journal:  Blood       Date:  2011-03-17       Impact factor: 22.113

4.  Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

Authors:  Grant A Challen; Nathan C Boles; Stuart M Chambers; Margaret A Goodell
Journal:  Cell Stem Cell       Date:  2010-03-05       Impact factor: 24.633

5.  Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.

Authors:  Simón Méndez-Ferrer; Tatyana V Michurina; Francesca Ferraro; Amin R Mazloom; Ben D Macarthur; Sergio A Lira; David T Scadden; Avi Ma'ayan; Grigori N Enikolopov; Paul S Frenette
Journal:  Nature       Date:  2010-08-12       Impact factor: 49.962

6.  Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment.

Authors:  Benedetto Sacchetti; Alessia Funari; Stefano Michienzi; Silvia Di Cesare; Stefania Piersanti; Isabella Saggio; Enrico Tagliafico; Stefano Ferrari; Pamela Gehron Robey; Mara Riminucci; Paolo Bianco
Journal:  Cell       Date:  2007-10-19       Impact factor: 41.582

7.  Enumeration of the colony-forming units-fibroblast from mouse and human bone marrow in normal and pathological conditions.

Authors:  Sergei A Kuznetsov; Mahesh H Mankani; Paolo Bianco; Pamela G Robey
Journal:  Stem Cell Res       Date:  2008-08-12       Impact factor: 2.020

8.  The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase.

Authors:  Malgorzata Sobiesiak; Kavitha Sivasubramaniyan; Clemens Hermann; Charmaine Tan; Melanie Orgel; Sabrina Treml; Flavianna Cerabona; Peter de Zwart; Uwe Ochs; Claudia A Müller; Caroline E Gargett; Hubert Kalbacher; Hans-Jörg Bühring
Journal:  Stem Cells Dev       Date:  2010-05       Impact factor: 3.272

9.  Novel markers for the prospective isolation of human MSC.

Authors:  Hans-Jörg Bühring; Venkata Lokesh Battula; Sabrina Treml; Bernhard Schewe; Lothar Kanz; Wichard Vogel
Journal:  Ann N Y Acad Sci       Date:  2007-03-29       Impact factor: 5.691

10.  Age-dependent demise of GNAS-mutated skeletal stem cells and "normalization" of fibrous dysplasia of bone.

Authors:  Sergei A Kuznetsov; Natasha Cherman; Mara Riminucci; Michael T Collins; Pamela Gehron Robey; Paolo Bianco
Journal:  J Bone Miner Res       Date:  2008-11       Impact factor: 6.741
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  35 in total

Review 1.  Stem cell heterogeneity: implications for aging and regenerative medicine.

Authors:  Christa E Muller-Sieburg; Hans B Sieburg; Jeff M Bernitz; Giulio Cattarossi
Journal:  Blood       Date:  2012-03-09       Impact factor: 22.113

2.  Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts.

Authors:  Sara M Melief; Jaap Jan Zwaginga; Willem E Fibbe; Helene Roelofs
Journal:  Stem Cells Transl Med       Date:  2013-05-21       Impact factor: 6.940

3.  Hematopoietic stem cell and mesenchymal stem cell population size in bone marrow samples depends on patient's age and harvesting technique.

Authors:  Katja Rebolj; Matija Veber; Matej Drobnič; Elvira Maličev
Journal:  Cytotechnology       Date:  2018-09-18       Impact factor: 2.058

4.  Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.

Authors:  Sabine Stopp; Martin Bornhäuser; Fernando Ugarte; Manja Wobus; Matthias Kuhn; Sebastian Brenner; Sebastian Thieme
Journal:  Haematologica       Date:  2012-07-16       Impact factor: 9.941

5.  Reduced levels of mesenchymal stem cells at the tendon-bone interface tuberosity in patients with symptomatic rotator cuff tear.

Authors:  Philippe Hernigou; Guillaume Merouse; Pascal Duffiet; Nathalie Chevalier; Helene Rouard
Journal:  Int Orthop       Date:  2015-03-12       Impact factor: 3.075

6.  Autologous tissue patch rich in stem cells created in the subcutaneous tissue.

Authors:  Ignacio Garcia-Gomez; Krishnamurthy P Gudehithlu; Jose A L Arruda; Ashok K Singh
Journal:  World J Stem Cells       Date:  2015-09-26       Impact factor: 5.326

Review 7.  Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: Characterization and role in human autoimmune diseases.

Authors:  Pradeep K Dagur; J Philip McCoy
Journal:  Autoimmun Rev       Date:  2015-01-13       Impact factor: 9.754

8.  Changes in Chondrogenic Progenitor Populations Associated with Aging and Osteoarthritis.

Authors:  Kyla Brady; Sally C Dickinson; Anthony P Hollander
Journal:  Cartilage       Date:  2015-03-24       Impact factor: 4.634

Review 9.  Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations.

Authors:  Rodrigo A Somoza; Jean F Welter; Diego Correa; Arnold I Caplan
Journal:  Tissue Eng Part B Rev       Date:  2014-05-27       Impact factor: 6.389

10.  Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.

Authors:  Kyla Brady; Sally C Dickinson; Pascale V Guillot; Julia Polak; Ashley W Blom; Wael Kafienah; Anthony P Hollander
Journal:  Stem Cells Dev       Date:  2013-12-04       Impact factor: 3.272
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