Interactions between microbes and the gut epithelium.

Gut microbes interact with the epithelium through cell surface components, fermentation products, and extracellular secreted proteins. Host-microbial interactions primarily involve TLRs (toll-like receptors) and NLR (nucleotide-binding oligomerization domain and leucine-rich repeat containing proteins). In a strain and dose-dependent manner, several probiotic strains directly alter tight junction protein expression and/or localization in gut epithelial cells through the release of secreted compounds. Interactions between gut microbes and intestinal epithelial and immune cells are necessary for the development and maintenance of intestinal homeostasis.