Chao Qin1, Jiande D Z Chen, Jing Zhang, Robert D Foreman. 1. Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; and Veteran Research Foundation, VA Medical Center, Oklahoma City, OK, USA.
Abstract
OBJECTIVES: The aim was to determine whether somatic afferent fiber stimulation influences thoracic spinal neuronal activity responding to gastric distensions. MATERIALS AND METHODS: Extracellular potentials of single T9-T10 spinal neurons were recorded in anesthetized male rats. Ipsilateral median and peroneal nerve afferent stimulation (MNAS, PNAS) was delivered by electrodes. Inflation of a latex balloon was used to produce gastric distension. RESULTS: MNAS and PNAS (1.5 mA, 50 Hz, 10 sec) altered activity of 63% and 66% of the spinal neurons excited or inhibited by gastric distension, respectively. MNAS more frequently reduced spinal neuronal activity with excitatory responses to gastric distension than did PNAS (p < 0.05). PNAS more likely increased neuronal activity with low-threshold excitatory responses to gastric distension than MNAS (p < 0.05). CONCLUSIONS: Peripheral somatic afferent information utilizes central pathways to modulate gastric afferent processing in T9-T10 spinal neurons. Thus, somatic afferent stimulation might be used to treat gastric pain and/or hypersensitivity.
OBJECTIVES: The aim was to determine whether somatic afferent fiber stimulation influences thoracic spinal neuronal activity responding to gastric distensions. MATERIALS AND METHODS: Extracellular potentials of single T9-T10 spinal neurons were recorded in anesthetized male rats. Ipsilateral median and peroneal nerve afferent stimulation (MNAS, PNAS) was delivered by electrodes. Inflation of a latex balloon was used to produce gastric distension. RESULTS: MNAS and PNAS (1.5 mA, 50 Hz, 10 sec) altered activity of 63% and 66% of the spinal neurons excited or inhibited by gastric distension, respectively. MNAS more frequently reduced spinal neuronal activity with excitatory responses to gastric distension than did PNAS (p < 0.05). PNAS more likely increased neuronal activity with low-threshold excitatory responses to gastric distension than MNAS (p < 0.05). CONCLUSIONS: Peripheral somatic afferent information utilizes central pathways to modulate gastric afferent processing in T9-T10 spinal neurons. Thus, somatic afferent stimulation might be used to treat gastric pain and/or hypersensitivity.
Authors: Li-Na Meng; Shanshan Chen; Jiande D Z Chen; Hai-Feng Jin; Bin Lu Journal: Evid Based Complement Alternat Med Date: 2016-08-28 Impact factor: 2.629