OBJECTIVE: To study the central effects of occipital nerve stimulation (ONS) using functional magnetic resonance imaging (fMRI). MATERIALS AND METHODS: After phantom measurements, blocked design fMRI scanning was performed during intermittent ONS in a healthy volunteer with implanted electrodes connected to an external generator. To assess the effect of frequency and stimulation mode, seven different frequencies in either tonic or burst mode were generated by a neurostimulator. RESULTS: A qualitative analysis of the main effect of ONS demonstrated significantly decreased activity within the bilateral primary visual, auditory, and somatosensory cortices and in the amygdala. Significant increased activity was observed bilaterally in the thalamus, frontal, and parietal areas and the cerebellum. Subsequently, quantitative analysis revealed that, unlike tonic mode stimulation, burst mode stimulation appeared to be frequency-dependent. CONCLUSIONS: This study demonstrates the feasibility and safety of fMRI studies with simultaneous ONS in a subject with externalized electrodes. The activation and deactivation pattern induced by ONS depends on stimulation mode and frequency.
OBJECTIVE: To study the central effects of occipital nerve stimulation (ONS) using functional magnetic resonance imaging (fMRI). MATERIALS AND METHODS: After phantom measurements, blocked design fMRI scanning was performed during intermittent ONS in a healthy volunteer with implanted electrodes connected to an external generator. To assess the effect of frequency and stimulation mode, seven different frequencies in either tonic or burst mode were generated by a neurostimulator. RESULTS: A qualitative analysis of the main effect of ONS demonstrated significantly decreased activity within the bilateral primary visual, auditory, and somatosensory cortices and in the amygdala. Significant increased activity was observed bilaterally in the thalamus, frontal, and parietal areas and the cerebellum. Subsequently, quantitative analysis revealed that, unlike tonic mode stimulation, burst mode stimulation appeared to be frequency-dependent. CONCLUSIONS: This study demonstrates the feasibility and safety of fMRI studies with simultaneous ONS in a subject with externalized electrodes. The activation and deactivation pattern induced by ONS depends on stimulation mode and frequency.
Authors: Rafael Caiado Vencio; Paulo Eduardo Albuquerque Zito Raffa; André Costa Corral Ponce; Bruno Pricoli Malamud; César Cozar Pacheco; Paulo Roberto Franceschini; Roger Thomaz Rotta Medeiros; Paulo Henrique Pires de Aguiar Journal: Surg Neurol Int Date: 2021-04-26
Authors: Shaheen Ahmed; Mark Plazier; Jan Ost; Gaetane Stassijns; Steven Deleye; Sarah Ceyssens; Patrick Dupont; Sigrid Stroobants; Steven Staelens; Dirk De Ridder; Sven Vanneste Journal: BMC Neurol Date: 2018-11-12 Impact factor: 2.474
Authors: Delphine Magis; Kevin D'Ostilio; Aurore Thibaut; Victor De Pasqua; Pascale Gerard; Roland Hustinx; Steven Laureys; Jean Schoenen Journal: Cephalalgia Date: 2016-06-23 Impact factor: 6.292