Trien conjugates, schiff bases, and ceruloplasmin concentrations as markers of the onset of the risk of autodermoplasty complications.

Background. Surgical interference which includes debridement and further renewal of skin cover by autodermoplasty (ADP) is the most effective method of burn wound treatment. Skin graft failure is a serious complication of ADP procedures leading to the opening of previously closed wounds, graft loss, and an increased wound surface owing to the donor zone. Numerous factors are involved that may affect the results of the ADP procedure. When planning the terms of surgical interference, specialists have to take into consideration criteria regarding the visual readiness of the wound and the patient's objective state. Aim. We studied the possibility of using concentrations of trien conjugates, Schiff bases, and ceruloplasmin in the plasma of patients with deep local wounds as markers of the risk of autoskin graft failure. Methods. Ninety patients with local wounds of different origin and age were studied. Results and conclusions. It was found out that the amounts of trien conjugates, Schiff bases, and ceruloplasmin in plasma before the operation helped to predict the risk of autoskin graft failure with a high degree of probability (up to 92%). We established optimum cut-off points for trien conjugates, Schiff bases, and ceruloplasmin as indicators of the results of autodermoplasty operations, i.e. 350 mg/l, 0.35 units of oxidation indices (UOI), and 0.05 UOI, respectively.