Literature DB >> 21991008

Management of keloid and hypertrophic scars.

A S Edriss1, J Mesták.   

Abstract

Scar management for the prevention of excessive scar formation has always been important but never so important as it is today. Optimal management continues to be an enigma for surgeons, and the best modality of treatment has been debated for many years. However, most studies have unfortunately been either retrospective or case report descriptions. Advances in scar management have been hampered by confusing or ambiguous terminology. There is no consensus on what amount of post-traumatic skin scar formation is "normal" and what should be considered "hypertrophic". In the World Health Organization's ICD-9, there is no diagnostic code for hypertrophic scar - only keloid is listed. Yet the medical and scientific literature distinguishes them as different conditions. This confusion results in inappropriate management of scar formation, and occasionally contributes to decision making related to elective or cosmetic surgery. Our experience suggests that there is no single treatment for scars that is adequate and that clinical judgement is very important when considering treatment and balancing the potential benefits of the various treatments available. The goal of treating scars is to restore functionality, provide relief of symptoms, enhance cosmetics, and prevent recurrence. This article is based on our scientific and clinical experiences and focuses on over-the-counter options to manage keloid and hypertrophic scars.

Entities:  

Keywords:  HYPERTROPHIC; KELOID; MANAGEMENT; SCARS

Year:  2005        PMID: 21991008      PMCID: PMC3187998     

Source DB:  PubMed          Journal:  Ann Burns Fire Disasters        ISSN: 1592-9558


  26 in total

1.  Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles.

Authors:  M Santucci; L Borgognoni; U M Reali; G Gabbiani
Journal:  Virchows Arch       Date:  2001-05       Impact factor: 4.064

Review 2.  Superficial x-ray therapy in keloid management: a retrospective study of 24 cases and literature review.

Authors:  J E Norris
Journal:  Plast Reconstr Surg       Date:  1995-05       Impact factor: 4.730

Review 3.  Management of scar contractures, hypertrophic scars, and keloids.

Authors:  D A Sherris; W F Larrabee; C S Murakami
Journal:  Otolaryngol Clin North Am       Date:  1995-10       Impact factor: 3.346

4.  Skin wound healing: transforming growth factor beta antagonists decrease scarring and improve quality.

Authors:  M W Ferguson
Journal:  J Interferon Res       Date:  1994-10

5.  Treatment of inflamed hypertrophic scars using intralesional 5-FU.

Authors:  R E Fitzpatrick
Journal:  Dermatol Surg       Date:  1999-03       Impact factor: 3.398

6.  Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings.

Authors:  C H Ricketts; L Martin; D T Faria; G M Saed; D P Fivenson
Journal:  Dermatol Surg       Date:  1996-11       Impact factor: 3.398

7.  Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts.

Authors:  J G Crowston; A N Akbar; P H Constable; N L Occleston; J T Daniels; P T Khaw
Journal:  Invest Ophthalmol Vis Sci       Date:  1998-02       Impact factor: 4.799

8.  Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature.

Authors:  A P Sclafani; L Gordon; M Chadha; T Romo
Journal:  Dermatol Surg       Date:  1996-06       Impact factor: 3.398

9.  Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars.

Authors:  J E Fulton
Journal:  Dermatol Surg       Date:  1995-11       Impact factor: 3.398

10.  Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts.

Authors:  M Varedi; E E Tredget; P G Scott; Y J Shen; A Ghahary
Journal:  J Invest Dermatol       Date:  1995-01       Impact factor: 8.551

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  11 in total

Review 1.  Novel Insights on Understanding of Keloid Scar: Article Review.

Authors:  Walid Mari; Sami G Alsabri; Najib Tabal; Sara Younes; Abdulamagid Sherif; Richard Simman
Journal:  J Am Coll Clin Wound Spec       Date:  2016-11-30

Review 2.  Extracellular DNA NET-Works With Dire Consequences for Health.

Authors:  Nicoletta Sorvillo; Deya Cherpokova; Kimberly Martinod; Denisa D Wagner
Journal:  Circ Res       Date:  2019-08-01       Impact factor: 17.367

3.  Full-Thickness Thermal Injury Delays Wound Closure in a Murine Model.

Authors:  Jesse C Wu; Lloyd F Rose; Robert J Christy; Kai P Leung; Rodney K Chan
Journal:  Adv Wound Care (New Rochelle)       Date:  2015-02-01       Impact factor: 4.730

4.  Surgical management of extensive hypertrophic scarring of the halluces secondary to a decade of untreated onychocryptosis: An illustrative case report.

Authors:  Dean J Samaras; Andrew C Kingsford
Journal:  SAGE Open Med Case Rep       Date:  2017-11-06

5.  Back Grafting the Split-Thickness Skin Graft Donor Site.

Authors:  Jeremy Goverman; Casey T Kraft; Shawn Fagan; Benjamin Levi
Journal:  J Burn Care Res       Date:  2017 Jan/Feb       Impact factor: 1.845

6.  Antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts.

Authors:  Mohamad Shah Nurul Syazana; Ahmad Sukari Halim; Siew Hua Gan; Shaharum Shamsuddin
Journal:  BMC Complement Altern Med       Date:  2011-09-26       Impact factor: 3.659

7.  Stem Cells in Keloid Lesions: A Review.

Authors:  Kim H Lim; Tinte Itinteang; Paul F Davis; Swee T Tan
Journal:  Plast Reconstr Surg Glob Open       Date:  2019-05-16

8.  When Testosterone Needs to be Contrasted: A Preliminary Study of Scar Prevention in Transmen Top Surgery with an Innovative Galenic Preparation.

Authors:  Sara Tanini; Sara Calabrese; Alessandra D Fisher; Mario Maggi; Giulia Lo Russo
Journal:  Aesthetic Plast Surg       Date:  2020-03-20       Impact factor: 2.326

Review 9.  Addressing Female Genital Mutilation/Cutting (FGM/C) in the Era of Clitoral Reconstruction: Plastic Surgery.

Authors:  Hannes Sigurjonsson; Malin Jordal
Journal:  Curr Sex Health Rep       Date:  2018-04-27

10.  Management of Ear Keloids Using Surgical Excision Combined with Postoperative Steroid Injections.

Authors:  Ali Akbar Mohammadi; Sina Kardeh; Gholam Reza Motazedian; Soheil Soheil
Journal:  World J Plast Surg       Date:  2019-09
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