Literature DB >> 21990105

Long-chain lipids are required for the innate immune recognition of trehalose diesters by macrophages.

Ashna A Khan1, Stephanie H Chee, Rene J McLaughlin, Jacquie L Harper, Faustin Kamena, Mattie S M Timmer, Bridget L Stocker.   

Abstract

Going to any length? Trehalose diesters of various chain lengths have been synthesised in order to determine the effect of lipid length on innate immune recognition, as determined by NO and cytokine production by macrophages. In this work, we show that longer lipids (C(20) -C(26)) are required for macrophage activation, with C(22) giving optimal activity.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21990105     DOI： 10.1002/cbic.201100451

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  13 in total

1.  MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1β Secretion.

Authors:  Kanu Wahi; Kristel Kodar; Melanie J McConnell; Jacquie L Harper; Mattie S M Timmer; Bridget L Stocker
Journal:  Inflammation       Date:  2019-06       Impact factor: 4.092

2.  The effects of trehalose glycolipid presentation on cytokine production by GM-CSF macrophages.

Authors:  Bridget L Stocker; Kristel Kodar; Kanu Wahi; Amy J Foster; Jacquie L Harper; Daiki Mori; Sho Yamasaki; Mattie S M Timmer
Journal:  Glycoconj J       Date:  2019-01-08       Impact factor: 2.916

3.  6,6'-Aryl trehalose analogs as potential Mincle ligands.

Authors:  Omer K Rasheed; George Ettenger; Cassandra Buhl; Robert Child; Shannon M Miller; Jay T Evans; Kendal T Ryter
Journal:  Bioorg Med Chem       Date:  2020-05-31       Impact factor: 3.641

4.  Rational design of adjuvants targeting the C-type lectin Mincle.

Authors:  Alexiane Decout; Sandro Silva-Gomes; Daniel Drocourt; Sophie Barbe; Isabelle André; Francisco J Cueto; Thierry Lioux; David Sancho; Eric Pérouzel; Alain Vercellone; Jacques Prandi; Martine Gilleron; Gérard Tiraby; Jérôme Nigou
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-21       Impact factor: 11.205

5.  Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.

Authors:  Atsushi Furukawa; Jun Kamishikiryo; Daiki Mori; Kenji Toyonaga; Yuki Okabe; Aya Toji; Ryo Kanda; Yasunobu Miyake; Toyoyuki Ose; Sho Yamasaki; Katsumi Maenaka
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-07       Impact factor: 11.205

6.  Design of Trehalose-Based Amide/Sulfonamide C-type Lectin Receptor Signaling Compounds.

Authors:  Omer K Rasheed; Cassandra Buhl; Jay T Evans; Kendal T Ryter
Journal:  ChemMedChem       Date:  2021-02-09       Impact factor: 3.466

Review 7.  Sensing Lipids with Mincle: Structure and Function.

Authors:  Spencer J Williams
Journal:  Front Immunol       Date:  2017-11-27       Impact factor: 7.561

8.  Interaction of Glycolipids with the Macrophage Surface Receptor Mincle - a Systematic Molecular Dynamics Study.

Authors:  Christian A Söldner; Anselm H C Horn; Heinrich Sticht
Journal:  Sci Rep       Date:  2018-03-29       Impact factor: 4.379

9.  Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo.

Authors:  Alexandra Huber; Rie S Kallerup; Karen S Korsholm; Henrik Franzyk; Bernd Lepenies; Dennis Christensen; Camilla Foged; Roland Lang
Journal:  Innate Immun       Date:  2016-06-01       Impact factor: 2.680

Review 10.  Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands.

Authors:  Chriselle D Braganza; Thomas Teunissen; Mattie S M Timmer; Bridget L Stocker
Journal:  Front Immunol       Date:  2018-01-17       Impact factor: 7.561
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