Literature DB >> 21989969

Developments towards regioselective synthesis of 1,2-disubstituted benzimidazoles.

Luísa C R Carvalho1, Eduarda Fernandes, M Manuel B Marques.   

Abstract

1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug discovery targets. Herein, several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimidazole assembly under microwave conditions.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21989969     DOI： 10.1002/chem.201101508

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  10 in total

1.  DDQ in mechanochemical C-N coupling reactions.

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Journal:  Beilstein J Org Chem       Date:  2022-06-01       Impact factor: 2.544

2.  Concise synthesis of N-thiomethyl benzoimidazoles through base-promoted sequential multicomponent assembly.

Authors:  Jingxin Tian; Shanshan Yuan; Fuhong Xiao; Huawen Huang; Guo-Jun Deng
Journal:  RSC Adv       Date:  2019-09-26       Impact factor: 4.036

3.  One pot three component reaction for the rapid synthesis of pyrrolo[1,2-a]benzimidazoles.

Authors:  Wei-Shun Hsu; Vijaykumar Paike; Chung-Ming Sun
Journal:  Mol Divers       Date:  2013-03-26       Impact factor: 2.943

4.  Cascade palladium catalysis: a predictable and selectable regiocontrolled synthesis of N-arylbenzimidazoles.

Authors:  Nathan T Jui; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-13       Impact factor: 15.336

5.  PIII /PV =O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles.

Authors:  Trevor V Nykaza; Gen Li; Junyu Yang; Michael R Luzung; Alexander T Radosevich
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-29       Impact factor: 15.336

6.  A bioinspired catalytic aerobic oxidative C-H functionalization of primary aliphatic amines: synthesis of 1,2-disubstituted benzimidazoles.

Authors:  Khac Minh Huy Nguyen; Martine Largeron
Journal:  Chemistry       Date:  2015-07-23       Impact factor: 5.236

7.  Crystal structure and UV spectra of a 1,2-disubstituted benzimidazolium chloride.

Authors:  Tuhin Khan; Navneet Mishra; Darshan S Mhatre; Anindya Datta
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-07-07

8.  Involvement of conformational isomerism in the complexity of the crystal network of 1-(4-nitrophenyl)-1H-1,3-benzimidazole derivatives driven by C-H...A (A = NO2, Npy and π) and orthogonal Npy...NO2 and ONO...Csp2 interactions.

Authors:  Mónica I García-Aranda; Carlos Z Gómez-Castro; Efrén V García-Báez; Yolanda Gómez Y Gómez; José L Castrejón-Flores; Itzia I Padilla-Martínez
Journal:  Acta Crystallogr C Struct Chem       Date:  2018-03-07       Impact factor: 1.172

Review 9.  Beyond a solvent: triple roles of dimethylformamide in organic chemistry.

Authors:  Majid M Heravi; Mahdieh Ghavidel; Leyla Mohammadkhani
Journal:  RSC Adv       Date:  2018-08-03       Impact factor: 4.036

10.  Aqueous synthesis of 1-H-2-substituted benzimidazoles via transition-metal-free intramolecular amination of aryl iodides.

Authors:  Chunxia Chen; Chen Chen; Bin Li; Jingwei Tao; Jinsong Peng
Journal:  Molecules       Date:  2012-10-24       Impact factor: 4.411
  10 in total

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