| Literature DB >> 21989459 |
Miho Uchida1, Satoshi Takamatsu, Shiho Arima, Kiyoko T Miyamoto, Shigeru Kitani, Takuya Nihira, Haruo Ikeda, Tohru Nagamitsu.
Abstract
The first total synthesis of extracellular factor, "Avenolide", in Streptomyces avermitilis has been achieved using a convergent approach. The stereogenic centers in two key segments were installed using Sharpless epoxidation and dihydroxylation. This synthetic study allowed the determination of the absolute configuration of avenolide as 4S,10R, and yielded important information on its structure-activity relationship.Entities:
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Year: 2011 PMID： 21989459 DOI： 10.1038/ja.2011.90
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649