| Literature DB >> 2198918 |
N C Hill1, M Selinger, J Ferguson, A López Bernal, I Z Mackenzie.
Abstract
A double-blind placebo-controlled trial was performed in 20 primigravidae to assess the physiological and clinical effects of oral mifepristone on myometrial contractility and sensitivity in the second trimester. Ten women received 600 mg of oral mifepristone and 10 women a placebo 24 h before abortion was induced in both groups, with extra-amniotic PGE2 instillation. Intrauterine pressure recordings demonstrated increased spontaneous uterine activity and increased sensitivity to PGE2 and ergometrine, but no change in oxytocin sensitivity after mifepristone treatment. There were no significant differences in PGE or PGF metabolite concentrations in peripheral maternal plasma over the 24-h study period after treatment between the mifepristone and placebo groups. The mean induction abortion interval in the mifepristone group was 512 (SD 321) min compared with 1128 (SD 606) min in the placebo group (P less than or equal to 0.02). The mechanism whereby mifepristone provokes enhanced uterine contractility and sensitivity to prostaglandins, with a reduction in abortion times, does not appear to be through endogenous production of PGE or PGF.Entities:
Keywords: Abortion, Induced; Biology; Data Analysis; Double-blind Studies; Endocrine System; Evaluation; Family Planning; Fertility Control, Postconception; Genitalia; Genitalia, Female; Hormone Antagonists; Hormones; Myometrial Effects; Myometrium; Oxytocin--administraction and dosage; Physiology; Pituitary Hormones; Pregnancy; Pregnancy, Second Trimester; Progestational Hormones; Progesterone--analysis; Prostaglandins--analysis; Reproduction; Research Methodology; Ru-486--administraction and dosage; Studies; Urogenital System; Uterus
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Year: 1990 PMID： 2198918 DOI： 10.1111/j.1471-0528.1990.tb02517.x
Source DB: PubMed Journal: Br J Obstet Gynaecol ISSN： 0306-5456