Literature DB >> 21988188

N-Bromosuccinimide promoted one-pot synthesis of guanidine: scope and mechanism.

Ling Zhou1, Jie Chen, Jing Zhou, Ying-Yeung Yeung.   

Abstract

A novel electrophilic one-pot guanidine synthesis has been developed using an olefin, a cyanimide, an amine, and N-bromosuccinimide. A number of guanidine derivatives were prepared with good to excellent yields. An rTRTVI precursor was also prepared based on this useful process.
© 2011 American Chemical Society

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Year:  2011        PMID: 21988188     DOI: 10.1021/ol202402y

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  3 in total

1.  A simple method for the electrophilic cyanation of secondary amines.

Authors:  Chen Zhu; Ji-Bao Xia; Chuo Chen
Journal:  Org Lett       Date:  2013-12-06       Impact factor: 6.005

2.  A solution-phase parallel synthesis of alkylated guanidines from thioisocyanates and amines.

Authors:  Andrey V Bogolubsky; Alexander Grishchenko; Sergey E Pipko; Anzhelika Konovets; Alexander Chuprina; Andrey Tolmachev; Alexander N Boyko; Alexey Chekotylo; Oleg Lukin
Journal:  Mol Divers       Date:  2013-05-01       Impact factor: 2.943

3.  Ritter-enabled catalytic asymmetric chloroamidation of olefins.

Authors:  Daniel C Steigerwald; Bardia Soltanzadeh; Aritra Sarkar; Cecilia C Morgenstern; Richard J Staples; Babak Borhan
Journal:  Chem Sci       Date:  2020-12-07       Impact factor: 9.825

  3 in total

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