CONTEXT: Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients. OBJECTIVE: To prospectively validate HNP as a biomarker for BOS. MATERIALS AND METHODS: HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients. RESULTS: The first HNP measurement after reaching baseline pulmonary function was predictive of developing BOS ≥2 (p = 0.0419). HNP remained elevated in those that developed BOS. The effect of potential confounders did not significantly impact BOS-free survival time. CONCLUSION: HNP levels are elevated early and persistently in those that develop BOS.
CONTEXT: Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients. OBJECTIVE: To prospectively validate HNP as a biomarker for BOS. MATERIALS AND METHODS:HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients. RESULTS: The first HNP measurement after reaching baseline pulmonary function was predictive of developing BOS ≥2 (p = 0.0419). HNP remained elevated in those that developed BOS. The effect of potential confounders did not significantly impact BOS-free survival time. CONCLUSION:HNP levels are elevated early and persistently in those that develop BOS.
Authors: Arya Biragyn; Pier Adelchi Ruffini; Cynthia A Leifer; Elena Klyushnenkova; Alexander Shakhov; Oleg Chertov; Aiko K Shirakawa; Joshua M Farber; David M Segal; Joost J Oppenheim; Larry W Kwak Journal: Science Date: 2002-11-01 Impact factor: 47.728
Authors: John A Belperio; Bruno DiGiovine; Michael P Keane; Marie D Burdick; Ying Ying Xue; David J Ross; Joseph P Lynch; Steven L Kunkel; Robert M Strieter Journal: Transplantation Date: 2002-02-27 Impact factor: 4.939
Authors: J A Belperio; M P Keane; M D Burdick; J P Lynch; Y Y Xue; A Berlin; D J Ross; S L Kunkel; I F Charo; R M Strieter Journal: J Clin Invest Date: 2001-08 Impact factor: 14.808
Authors: L Zheng; E H Walters; C Ward; N Wang; B Orsida; H Whitford; T J Williams; T Kotsimbos; G I Snell Journal: Thorax Date: 2000-01 Impact factor: 9.139
Authors: Jamil Aarbiou; Renate M Verhoosel; Sandra Van Wetering; Willem I De Boer; J Han J M Van Krieken; Sergey V Litvinov; Klaus F Rabe; Pieter S Hiemstra Journal: Am J Respir Cell Mol Biol Date: 2003-07-18 Impact factor: 6.914