Literature DB >> 21987590

Simvastatin modulates the Alzheimer's disease-related gene seladin-1.

Maria C Ramos1, Saleta Sierra, Carlos Ramirez, Javier Velasco, Javier S Burgos.   

Abstract

This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.

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Year:  2012        PMID： 21987590     DOI： 10.3233/JAD-2011-111118

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  4 in total

1.  Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines.

Authors:  Kai Yao; Junfeng Wu; Jianfeng Zhang; Jimei Bo; Zhen Hong; Hengbing Zu
Journal:  Cell Mol Neurobiol       Date:  2015-09-04       Impact factor: 5.046

2.  The Effect of Statins on Blood Gene Expression in COPD.

Authors:  Ma'en Obeidat; Nick Fishbane; Yunlong Nie; Virginia Chen; Zsuzsanna Hollander; Scott J Tebbutt; Yohan Bossé; Raymond T Ng; Bruce E Miller; Bruce McManus; Stephen Rennard; Peter D Paré; Don D Sin
Journal:  PLoS One       Date:  2015-10-13       Impact factor: 3.240

3.  Simvastatin inhibits the apoptosis of hippocampal cells in a mouse model of Alzheimer's disease.

Authors:  Xiaoqin Hu; Chengwei Song; Ming Fang; Chengyan Li
Journal:  Exp Ther Med       Date:  2017-12-12       Impact factor: 2.447

4.  Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.

Authors:  Xiao-Bo Yang; Heng-Bing Zu; Yong-Fei Zhao; Kai Yao
Journal:  Front Aging Neurosci       Date:  2022-01-27       Impact factor: 5.750
  4 in total

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