Literature DB >> 21986828

Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition.

Franka Teuscher1, Nanhua Chen, Dennis E Kyle, Michelle L Gatton, Qin Cheng.   

Abstract

The appearance of Plasmodium falciparum parasites with decreased in vivo sensitivity but no measurable in vitro resistance to artemisinin has raised the urgent need to characterize the artemisinin resistance phenotype. Changes in the temporary growth arrest (dormancy) profile of parasites may be one aspect of this phenotype. In this study, we investigated the link between dormancy and resistance, using artelinic acid (AL)-resistant parasites. Our results demonstrate that the AL resistance phenotype has (i) decreased sensitivity of mature-stage parasites, (ii) decreased sensitivity of the ring stage to the induction of dormancy, and (iii) a faster recovery from dormancy.

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Year:  2011        PMID： 21986828      PMCID： PMC3256014          DOI： 10.1128/AAC.05456-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Evidence of artemisinin-resistant malaria in western Cambodia.

Authors:  Harald Noedl; Youry Se; Kurt Schaecher; Bryan L Smith; Duong Socheat; Mark M Fukuda
Journal:  N Engl J Med       Date:  2008-12-08       Impact factor: 91.245

2.  Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.

Authors:  Marina Chavchich; Lucia Gerena; Jennifer Peters; Nanhua Chen; Qin Cheng; Dennis E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

3.  Deamplification of pfmdr1-containing amplicon on chromosome 5 in Plasmodium falciparum is associated with reduced resistance to artelinic acid in vitro.

Authors:  Nanhua Chen; Marina Chavchich; Jennifer M Peters; Dennis E Kyle; Michelle L Gatton; Qin Cheng
Journal:  Antimicrob Agents Chemother       Date:  2010-04-26       Impact factor: 5.191

4.  Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum.

Authors:  Mallika Imwong; Arjen M Dondorp; Francois Nosten; Poravuth Yi; Mathirut Mungthin; Sarun Hanchana; Debashish Das; Aung Phae Phyo; Khin Maung Lwin; Sasithon Pukrittayakamee; Sue J Lee; Suwannee Saisung; Kitti Koecharoen; Chea Nguon; Nicholas P J Day; Duong Socheat; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2010-04-26       Impact factor: 5.191

5.  Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure.

Authors:  Franka Teuscher; Michelle L Gatton; Nanhua Chen; Jennifer Peters; Dennis E Kyle; Qin Cheng
Journal:  J Infect Dis       Date:  2010-11-01       Impact factor: 5.226

6.  Intrahost modeling of artemisinin resistance in Plasmodium falciparum.

Authors:  Sompob Saralamba; Wirichada Pan-Ngum; Richard J Maude; Sue J Lee; Joel Tarning; Niklas Lindegårdh; Kesinee Chotivanich; François Nosten; Nicholas P J Day; Duong Socheat; Nicholas J White; Arjen M Dondorp; Lisa J White
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-20       Impact factor: 11.205

7.  Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism.

Authors:  Benoit Witkowski; Joel Lelièvre; María José López Barragán; Victor Laurent; Xin-zhuan Su; Antoine Berry; Françoise Benoit-Vical
Journal:  Antimicrob Agents Chemother       Date:  2010-02-16       Impact factor: 5.191

Review 8.  Qinghaosu (artemisinin): the price of success.

Authors:  N J White
Journal:  Science       Date:  2008-04-18       Impact factor: 47.728

9.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

10.  Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure.

Authors:  Andrea Codd; Franka Teuscher; Dennis E Kyle; Qin Cheng; Michelle L Gatton
Journal:  Malar J       Date:  2011-03-08       Impact factor: 2.979
  10 in total
  33 in total

1.  Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

Authors:  Andreas Martin Lisewski; Joel P Quiros; Caroline L Ng; Anbu Karani Adikesavan; Kazutoyo Miura; Nagireddy Putluri; Richard T Eastman; Daniel Scanfeld; Sam J Regenbogen; Lindsey Altenhofen; Manuel Llinás; Arun Sreekumar; Carole Long; David A Fidock; Olivier Lichtarge
Journal:  Cell       Date:  2014-08-14       Impact factor: 41.582

2.  Multiple Phenotypic and Genotypic Artemisinin Sensitivity Evaluation of Malian Plasmodium falciparum Isolates.

Authors:  Karamoko Niaré; Lucie Paloque; Sandie Ménard; Pety Tor; Arba P Ramadani; Jean-Michel Augereau; Antoine Dara; Antoine Berry; Françoise Benoit-Vical; Ogobara K Doumbo
Journal:  Am J Trop Med Hyg       Date:  2018-02-08       Impact factor: 2.345

Review 3.  Antimalarial Drug Resistance: A Threat to Malaria Elimination.

Authors:  Didier Menard; Arjen Dondorp
Journal:  Cold Spring Harb Perspect Med       Date:  2017-07-05       Impact factor: 6.915

4.  Distinct amino acid and lipid perturbations characterize acute versus chronic malaria.

Authors:  Regina Joice Cordy; Rapatbhorn Patrapuvich; Loukia N Lili; Monica Cabrera-Mora; Jung-Ting Chien; Gregory K Tharp; Manoj Khadka; Esmeralda Vs Meyer; Stacey A Lapp; Chester J Joyner; AnaPatricia Garcia; Sophia Banton; ViLinh Tran; Viravarn Luvira; Siriwan Rungin; Teerawat Saeseu; Nattawan Rachaphaew; Suman B Pakala; Jeremy D DeBarry; Jessica C Kissinger; Eric A Ortlund; Steven E Bosinger; John W Barnwell; Dean P Jones; Karan Uppal; Shuzhao Li; Jetsumon Sattabongkot; Alberto Moreno; Mary R Galinski
Journal:  JCI Insight       Date:  2019-05-02

5.  Upregulation of gametocytogenesis in anti-malarial drug-resistant Plasmodium falciparum.

Authors:  Thavamani Rajapandi
Journal:  J Parasit Dis       Date:  2019-04-03

6.  Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?

Authors:  Qin Cheng; Dennis E Kyle; Michelle L Gatton
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2012-01-27       Impact factor: 4.077

7.  Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia.

Authors:  Benoit Witkowski; Nimol Khim; Pheaktra Chim; Saorin Kim; Sopheakvatey Ke; Nimol Kloeung; Sophy Chy; Socheat Duong; Rithea Leang; Pascal Ringwald; Arjen M Dondorp; Rupam Tripura; Françoise Benoit-Vical; Antoine Berry; Olivier Gorgette; Frédéric Ariey; Jean-Christophe Barale; Odile Mercereau-Puijalon; Didier Menard
Journal:  Antimicrob Agents Chemother       Date:  2012-12-03       Impact factor: 5.191

8.  A nucleolar AAA-NTPase is required for parasite division.

Authors:  Elena S Suvorova; Joshua B Radke; Li-Min Ting; Sumiti Vinayak; Carmelo A Alvarez; Stella Kratzer; Kami Kim; Boris Striepen; Michael W White
Journal:  Mol Microbiol       Date:  2013-09-11       Impact factor: 3.501

9.  Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum.

Authors:  Nanhua Chen; Alexis N LaCrue; Franka Teuscher; Norman C Waters; Michelle L Gatton; Dennis E Kyle; Qin Cheng
Journal:  Antimicrob Agents Chemother       Date:  2014-06-09       Impact factor: 5.191

10.  Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency.

Authors:  Min Zhang; Julio Gallego-Delgado; Cristina Fernandez-Arias; Norman C Waters; Ana Rodriguez; Moriya Tsuji; Ronald C Wek; Victor Nussenzweig; William J Sullivan
Journal:  Cell Host Microbe       Date:  2017-12-13       Impact factor: 21.023
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