| Literature DB >> 21986586 |
Timothy C Gahman1, Mark R Herbert, Henk Lang, Angie Thayer, Kent T Symons, Phan Manh Nguyen, Mark E Massari, Sara Dozier, Yan Zhang, Marciano Sablad, Tadimeti S Rao, Stewart A Noble, Andrew K Shiau, Christian A Hassig.
Abstract
We have identified and synthesized a series of imidazole containing dimerization inhibitors of inducible nitric oxide synthase (iNOS). The necessity of key imidazole and piperonyl functionality was demonstrated and SAR studies led to the identification of compound 35, which showed a dose dependant inhibition in multiple pain models, including tactile allodynia induced by spinal nerve ligation (Chung model).Entities:
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Year: 2011 PMID： 21986586 DOI： 10.1016/j.bmcl.2011.08.112
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823