| Literature DB >> 21986585 |
Carla Ríos-Luci1, Raquel Domínguez-Kelly, Leticia G León, Elena Díaz-Rodríguez, Raimundo Freire, Atanasio Pandiella, Inga Cikotiene, José M Padrón.
Abstract
A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21986585 DOI： 10.1016/j.bmcl.2011.09.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823