BACKGROUND: Recent studies indicate that mast cells are more abundant in the obese state. Total serum tryptase (ST) is a marker of mast cell numbers or activity. Since obesity and asthma have been consistently linked in epidemiological studies, a possible higher mast cell activity in obesity could be a factor between the two conditions. The aim of this study was to investigate determinants of ST and whether a potential association between obesity and allergic respiratory disease would be influenced by levels of ST in obese persons. METHODS: Measurements of ST (ImmunoCAP Tryptase assay), atopy (skin prick test reactivity), methacholine bronchial hyperresponsiveness (BHR), body mass index (BMI) and serum lipids were performed in a general population of 1,216 persons aged 15-69 years. RESULTS: ST increased significantly with increasing BMI. The median ST level increased from 3.3 μg/l in persons with BMI <25 to 4.4 μg/l in persons with BMI >30, p < 0.0001. Age (p < 0.0001), male sex (p = 0.0009) and smoking (p = 0.022) were positively associated with ST, whereas alcohol consumption (p = 0.005) was inversely associated with ST. ST was not associated with atopy, symptoms of allergic respiratory disease or BHR. A positive association between symptoms of allergic respiratory disease and obesity (OR = 1.98, 95% CI = 1.25-3.14) was not influenced by obesity-related differences in ST. CONCLUSIONS: Increasing BMI was significantly associated with increasing ST and the prevalence of symptoms of allergic respiratory disease. However, mast cell activity/burden (assessed by ST levels) did not influence the association between BMI and asthma/rhinitis symptoms.
BACKGROUND: Recent studies indicate that mast cells are more abundant in the obese state. Total serum tryptase (ST) is a marker of mast cell numbers or activity. Since obesity and asthma have been consistently linked in epidemiological studies, a possible higher mast cell activity in obesity could be a factor between the two conditions. The aim of this study was to investigate determinants of ST and whether a potential association between obesity and allergic respiratory disease would be influenced by levels of ST in obesepersons. METHODS: Measurements of ST (ImmunoCAP Tryptase assay), atopy (skin prick test reactivity), methacholinebronchial hyperresponsiveness (BHR), body mass index (BMI) and serum lipids were performed in a general population of 1,216 persons aged 15-69 years. RESULTS: ST increased significantly with increasing BMI. The median ST level increased from 3.3 μg/l in persons with BMI <25 to 4.4 μg/l in persons with BMI >30, p < 0.0001. Age (p < 0.0001), male sex (p = 0.0009) and smoking (p = 0.022) were positively associated with ST, whereas alcohol consumption (p = 0.005) was inversely associated with ST. ST was not associated with atopy, symptoms of allergic respiratory disease or BHR. A positive association between symptoms of allergic respiratory disease and obesity (OR = 1.98, 95% CI = 1.25-3.14) was not influenced by obesity-related differences in ST. CONCLUSIONS: Increasing BMI was significantly associated with increasing ST and the prevalence of symptoms of allergic respiratory disease. However, mast cell activity/burden (assessed by ST levels) did not influence the association between BMI and asthma/rhinitis symptoms.
Authors: Aubri M Waters; Hyun J Park; Andrew L Weskamp; Allyson Mateja; Megan E Kachur; Jonathan J Lyons; Benjamin J Rosen; Nathan A Boggs Journal: J Allergy Clin Immunol Pract Date: 2022-01-12
Authors: Runa V Fenger; Arturo Gonzalez-Quintela; Carmen Vidal; Lise-Lotte Husemoen; Tea Skaaby; Betina H Thuesen; Mette Aadahl; Flemming Madsen; Allan Linneberg Journal: BMC Pulm Med Date: 2014-12-22 Impact factor: 3.317
Authors: Lakshmi Arivazhagan; Henry H Ruiz; Robin A Wilson; Michaele B Manigrasso; Paul F Gugger; Edward A Fisher; Kathryn J Moore; Ravichandran Ramasamy; Ann Marie Schmidt Journal: Circ Res Date: 2020-05-21 Impact factor: 17.367
Authors: Ada Weinstock; Hernandez Moura Silva; Kathryn J Moore; Ann Marie Schmidt; Edward A Fisher Journal: Circ Res Date: 2020-05-21 Impact factor: 17.367