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Literature DB >> 21984850

Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy) decanoic acid, a Precursor to the Unusual Amino Acid Residue of the Anticancer Agent Microsporin B.

Abstract

(S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy) decanoic acid, the Boc-protected precursor of an unusual amino acid residue for the synthesis of microsporin B, was synthesized. The key steps include a Suzuki coupling followed by asymmetric homogeneous hydrogenation.

Entities: CellLine Chemical Disease Gene Species

Year: 2011 PMID： 21984850 PMCID： PMC3185362 DOI： 10.1016/j.tetlet.2011.07.132

Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415

16 in total

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Review 7. Histone deacetylase inhibitors as potent modulators of cellular contacts.

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8. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

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Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy) decanoic acid, a Precursor to the Unusual Amino Acid Residue of the Anticancer Agent Microsporin B.

Review 1. Deacetylase enzymes: biological functions and the use of small-molecule inhibitors.

2. Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.

Review 3. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.

Review 4. Rational design of non-hydroxamate histone deacetylase inhibitors.

Review 5. Chemistry and biology of chromatin remodeling agents: state of art and future perspectives of HDAC inhibitors.

6. [Isolation and structural clarification of chlamydocin].

Review 7. Histone deacetylase inhibitors as potent modulators of cellular contacts.

8. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

Review 9. Chromatin remodeling, cancer and chemotherapy.

Review 10. Histone deacetylase inhibitors: multifunctional anticancer agents.

Review 1. A look around the West Indies: The spices of life are secondary metabolites.

Review 2. Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy.