Literature DB >> 2198480

The molecular basis of brain injury and brain edema: the role of oxygen free radicals.

Y Ikeda1, D M Long.   

Abstract

This review article outlines basic concepts and pathophysiological aspects of the chemistry of oxygen free radicals in all forms of brain injury and brain edema. Recent experimental studies have demonstrated that oxygen free radicals may be important mediators of brain injury and brain edema, and pharmacological antagonism of oxygen free radicals shows beneficial therapeutic results. A number of fundamental questions need to resolved, and advanced techniques for detecting oxygen free radicals will be needed. No clinical data are available, but oxygen free radical scavengers may possibly become a critical therapeutic modality for brain injury and brain edema.

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Year:  1990        PMID： 2198480     DOI： 10.1097/00006123-199007000-00001

Source DB:  PubMed          Journal:  Neurosurgery        ISSN： 0148-396X            Impact factor:   4.654


  45 in total

1.  Neuroprotective effects of N-acetylcysteine on experimental closed head trauma in rats.

Authors:  Tufan Hicdonmez; Mehmet Kanter; Mehmet Tiryaki; Turgay Parsak; Sebahattin Cobanoglu
Journal:  Neurochem Res       Date:  2006-05-09       Impact factor: 3.996

2.  The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography.

Authors:  H Qian; D Liu
Journal:  Neurochem Res       Date:  1997-10       Impact factor: 3.996

Review 3.  Multifunctional drugs for head injury.

Authors:  Robert Vink; Alan J Nimmo
Journal:  Neurotherapeutics       Date:  2009-01       Impact factor: 7.620

Review 4.  The roles of free radicals in amyotrophic lateral sclerosis.

Authors:  D Liu
Journal:  J Mol Neurosci       Date:  1996       Impact factor: 3.444

Review 5.  Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury?

Authors:  Kyle R Gronbeck; Cecilia M P Rodrigues; Javad Mahmoudi; Eric M Bershad; Geoffrey Ling; Salam P Bachour; Afshin A Divani
Journal:  Neurocrit Care       Date:  2016-08       Impact factor: 3.210

Review 6.  Biomarkers in traumatic brain injury.

Authors:  Richa Sharma; Daniel T Laskowitz
Journal:  Curr Neurol Neurosci Rep       Date:  2012-10       Impact factor: 5.081

Review 7.  Measurements in vivo of parameters pertinent to ROS/RNS using EPR spectroscopy.

Authors:  Nadeem Khan; Harold Swartz
Journal:  Mol Cell Biochem       Date:  2002 May-Jun       Impact factor: 3.396

8.  Antitumor and antioxidant role of Chrysaora quinquecirrha (sea nettle) nematocyst venom peptide against Ehrlich ascites carcinoma in Swiss Albino mice.

Authors:  Elumalai Balamurugan; Bandugula Venkata Reddy; Venugopal Padmanaban Menon
Journal:  Mol Cell Biochem       Date:  2009-12-11       Impact factor: 3.396

9.  Relations between the selenium status and the low T3 syndrome after major trauma.

Authors:  M M Berger; T Lemarchand-Béraud; C Cavadini; R Chioléro
Journal:  Intensive Care Med       Date:  1996-06       Impact factor: 17.440

10.  Tungsten treatment prevents tumor necrosis factor-induced injury of brain endothelial cells.

Authors:  L S Terada; I R Willingham; D M Guidot; G N Shibao; G W Kindt; J E Repine
Journal:  Inflammation       Date:  1992-02       Impact factor: 4.092
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