OBJECTIVES: Consensus is lacking on the immunological tests to perform for diagnosis of interstitial lung diseases (ILDs). In particular, the value of detecting anti-SSA antibody in this context is unknown. We aimed to determine whether the detection of anti-SSA antibody in patients with ILD can identify a subgroup of patients with CTD. METHODS: We compared the characteristics of patients with newly diagnosed apparently idiopathic ILD with anti-SSA antibody [anti-SSA(+) group] and without anti-SSA antibody (control group). RESULTS; Anti-SSA(+) patients (n = 15) more often had extra-respiratory signs (xerostomia and ocular dryness), auto-immune features, a CT scan pattern of non-specific interstitial pneumonia and more severe lung function alteration than controls (n = 30). Of patients who were anti-SSA(+), 2 met the criteria for SS and 13 (86%) of 15 met the criteria for the diagnosis of undifferentiated CTD. CONCLUSIONS: Our results suggest that identification of anti-SSA antibody in patients with early ILD can reveal a specific subgroup of patients with more ground glass opacity and more severe lung function impairment than those without anti-SSA antibody.
OBJECTIVES: Consensus is lacking on the immunological tests to perform for diagnosis of interstitial lung diseases (ILDs). In particular, the value of detecting anti-SSA antibody in this context is unknown. We aimed to determine whether the detection of anti-SSA antibody in patients with ILD can identify a subgroup of patients with CTD. METHODS: We compared the characteristics of patients with newly diagnosed apparently idiopathic ILD with anti-SSA antibody [anti-SSA(+) group] and without anti-SSA antibody (control group). RESULTS; Anti-SSA(+) patients (n = 15) more often had extra-respiratory signs (xerostomia and ocular dryness), auto-immune features, a CT scan pattern of non-specific interstitial pneumonia and more severe lung function alteration than controls (n = 30). Of patients who were anti-SSA(+), 2 met the criteria for SS and 13 (86%) of 15 met the criteria for the diagnosis of undifferentiated CTD. CONCLUSIONS: Our results suggest that identification of anti-SSA antibody in patients with early ILD can reveal a specific subgroup of patients with more ground glass opacity and more severe lung function impairment than those without anti-SSA antibody.
Authors: Ana Catarina Duarte; Ana Cordeiro; Bruno Miguel Fernandes; Miguel Bernardes; Patrícia Martins; Inês Cordeiro; Tânia Santiago; Maria Inês Seixas; Ana Roxo Ribeiro; Maria José Santos Journal: Clin Rheumatol Date: 2019-04-23 Impact factor: 2.980
Authors: Katerina D Samara; Athina Trachalaki; Eliza Tsitoura; Anastasios V Koutsopoulos; Eleni D Lagoudaki; Ismini Lasithiotaki; George Margaritopoulos; Panagiotis Pantelidis; Eleni Bibaki; Nikolaos M Siafakas; Nikolaos Tzanakis; Athol U Wells; Katerina M Antoniou Journal: Respir Res Date: 2017-12-29
Authors: Jorge I Ramírez Sepúlveda; Marika Kvarnström; Per Eriksson; Thomas Mandl; Katrine Brække Norheim; Svein Joar Johnsen; Daniel Hammenfors; Malin V Jonsson; Kathrine Skarstein; Johan G Brun; Lars Rönnblom; Helena Forsblad-d'Elia; Sara Magnusson Bucher; Eva Baecklund; Elke Theander; Roald Omdal; Roland Jonsson; Gunnel Nordmark; Marie Wahren-Herlenius Journal: Biol Sex Differ Date: 2017-08-08 Impact factor: 5.027