OBJECTIVE: To investigate the association of whole-blood fatty acids and reported intakes of fats with risk of prostate cancer (PCa). DESIGN: Case-control study of 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics. Whole-blood fatty acid composition (mol%) was measured by gas chromatography and diet assessed by food frequency questionnaire. RESULTS: High whole-blood oleic acid composition (tertile 3 vs. tertile 1: OR, 0.37; CI, 0.14-0.0.98) and moderate palmitic acid proportions (tertile 2: OR, 0.29; CI, 0.12-0.70) (tertile 3: OR, 0.53; CI, 0.19-1.54) were inversely related to risk of PCa, whereas men with high linolenic acid proportions were at increased likelihood of PCa (tertile 3 vs. tertile 1: OR, 2.06; 1.29-3.27). Blood myristic, stearic and palmitoleic acids were not associated with PCa. Higher intakes of dietary MUFA were inversely related to prostate cancer (tertile 3 vs. tertile 1: OR, 0.39; CI 0.16-0.92). The principal source of dietary MUFA was avocado intake. Dietary intakes of other fats were not associated with PCa. CONCLUSIONS: Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer. These associations warrant further investigation.
OBJECTIVE: To investigate the association of whole-blood fatty acids and reported intakes of fats with risk of prostate cancer (PCa). DESIGN: Case-control study of 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics. Whole-blood fatty acid composition (mol%) was measured by gas chromatography and diet assessed by food frequency questionnaire. RESULTS: High whole-blood oleic acid composition (tertile 3 vs. tertile 1: OR, 0.37; CI, 0.14-0.0.98) and moderate palmitic acid proportions (tertile 2: OR, 0.29; CI, 0.12-0.70) (tertile 3: OR, 0.53; CI, 0.19-1.54) were inversely related to risk of PCa, whereas men with high linolenic acid proportions were at increased likelihood of PCa (tertile 3 vs. tertile 1: OR, 2.06; 1.29-3.27). Blood myristic, stearic and palmitoleic acids were not associated with PCa. Higher intakes of dietary MUFA were inversely related to prostate cancer (tertile 3 vs. tertile 1: OR, 0.39; CI 0.16-0.92). The principal source of dietary MUFA was avocado intake. Dietary intakes of other fats were not associated with PCa. CONCLUSIONS: Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer. These associations warrant further investigation.
Authors: Bhawna Dubey; Maria D Jackson; Charnita Zeigler-Johnson; Karthik Devarajan; Rafael E Flores-Obando; Norma McFarlane-Anderson; Marshall K Tulloch-Reid; William Aiken; Kevin Kimbro; Dominique Z Jones; LaCreis R Kidd; Camille Ragin Journal: Gene Date: 2017-09-10 Impact factor: 3.688
Authors: Jorge E Chavarro; Stacey A Kenfield; Meir J Stampfer; Massimo Loda; Hannia Campos; Howard D Sesso; Jing Ma Journal: Am J Epidemiol Date: 2013-08-28 Impact factor: 4.897
Authors: Lacreis R Kidd; Dominique Z Jones; Erica N Rogers; Nayla C Kidd; Sydney Beache; James E Rudd; Camille Ragin; Maria Jackson; Norma McFarlane-Anderson; Marshall Tulloch-Reid; Seian Morrison; Guy N Brock; Shirish S Barve; Kevin S Kimbro Journal: Hered Cancer Clin Pract Date: 2012-11-20 Impact factor: 2.857
Authors: E N Rogers; D Z Jones; N C Kidd; S Yeyeodu; G Brock; C Ragin; M Jackson; N McFarlane-Anderson; M Tulloch-Reid; K Sean Kimbro; L R Kidd Journal: Genes Immun Date: 2013-05-09 Impact factor: 2.676