Literature DB >> 21984267

Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71.

Qunying Mao1, Nan Li, Xiang Yu, Xin Yao, Fengxiang Li, Fengmin Lu, Hui Zhuang, Zhenglun Liang, Junzhi Wang.   

Abstract

Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease. Recently, several EV71 inactivated vaccine candidates have been development in mainland China. To compare the antigenicity and genetic characteristics of different candidate vaccine strains for EV71, the genomes of 11 EV71 strains were sequenced. The cross-protection capacities were determined by neutralizing antibody test and were further assessed in neonatal mice. The results showed 93.0%-99.8% genome homology of the VP1 regions, but their cross-neutralization capacities varied. These results showed that vaccine strains with good cross-neutralization capacities had the potential to be vaccine strains.

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Year:  2011        PMID： 21984267     DOI： 10.1007/s00705-011-1136-3

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  27 in total

1.  Development of a sandwich ELISA for the quantification of enterovirus 71.

Authors:  Shujun Ma; Qunying Mao; Zhenglun Liang; Cuijuan Zhang; Wenxing Yang; Zhe Sun; Haijiang Zhang; Xinliang Shen; Shengli Bi; Le Sun
Journal:  Cytotechnology       Date:  2013-06-02       Impact factor: 2.058

2.  The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems.

Authors:  Wen Qi An; Zhi Guo Su; Ruo Wen Pan; Bao Ping Yang; Yong Chao Zhang; Liang Shi; Qing Li
Journal:  Hum Vaccin Immunother       Date:  2014-01-08       Impact factor: 3.452

3.  Development and characterization of an enterovirus 71 (EV71) virus-like particles (VLPs) vaccine produced in Pichia pastoris.

Authors:  Zhijian Yang; Fan Gao; Xiaoliang Wang; Likang Shi; Zheng Zhou; Yuanxiang Jiang; Xinxing Ma; Chao Zhang; Chenliang Zhou; Xianfang Zeng; Ge Liu; Jiang Fan; Qunying Mao; Li Shi
Journal:  Hum Vaccin Immunother       Date:  2019-08-15       Impact factor: 3.452

4.  The Pathogenesis and Prevention of Encephalitis due to Human Enterovirus 71.

Authors:  Emily Jane Bek; Peter Charles McMinn
Journal:  Curr Infect Dis Rep       Date:  2012-08       Impact factor: 3.725

Review 5.  Progress on the research and development of human enterovirus 71 (EV71) vaccines.

Authors:  Zhenglun Liang; Qunying Mao; Fan Gao; Junzhi Wang
Journal:  Front Med       Date:  2012-12-17       Impact factor: 4.592

6.  Poorly neutralizing polyclonal antibody in vitro against coxsackievirus A16 circulating strains can prevent a lethal challenge in vivo.

Authors:  Xin Yao; QunYing Mao; Yajing Li; Chunsheng Hao; LianLian Bian; Pan Chen; Fan Gao; Xing Wu; WeiWei Lu; Qiang Gao; XiuLing Li; Zhenglun Liang
Journal:  Hum Vaccin Immunother       Date:  2018-02-15       Impact factor: 3.452

7.  Comparative analysis of the immunogenicity and protective effects of inactivated EV71 vaccines in mice.

Authors:  Qunying Mao; Chenghong Dong; Xiuling Li; Qiang Gao; Zengbing Guo; Xin Yao; Yiping Wang; Fan Gao; Fengxiang Li; Miao Xu; Weidong Yin; Qihan Li; Xinliang Shen; Zhenglun Liang; Junzhi Wang
Journal:  PLoS One       Date:  2012-09-28       Impact factor: 3.240

8.  Development and evaluation of a pseudovirus-luciferase assay for rapid and quantitative detection of neutralizing antibodies against enterovirus 71.

Authors:  Xing Wu; Qunying Mao; Xin Yao; Pan Chen; Xiangmei Chen; Jie Shao; Fan Gao; Xiang Yu; Fengcai Zhu; Rongcheng Li; Wenhui Li; Zhenglun Liang; Junzhi Wang; Fengmin Lu
Journal:  PLoS One       Date:  2013-06-05       Impact factor: 3.240

9.  Immunological and biochemical characterization of coxsackie virus A16 viral particles.

Authors:  Pele Chong; Meng-Shin Guo; Fion Hsiao-Yu Lin; Kuang-Nan Hsiao; Shu-Yang Weng; Ai-Hsiang Chou; Jen-Ren Wang; Shih-Yang Hsieh; Ih-Jen Su; Chia-Chyi Liu
Journal:  PLoS One       Date:  2012-11-30       Impact factor: 3.240

10.  Mapping Enterovirus A71 Antigenic Determinants from Viral Evolution.

Authors:  Sheng-Wen Huang; Ching-Hui Tai; Judith M Fonville; Chin-Hui Lin; Shih-Min Wang; Ching-Chung Liu; Ih-Jen Su; Derek J Smith; Jen-Ren Wang
Journal:  J Virol       Date:  2015-09-02       Impact factor: 5.103
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