BACKGROUND AND PURPOSE: Hemodynamic stimulation has been suggested to affect the growth of cerebral aneurysms. The present study examined the effects of intra-aneurysmal hemodynamics on aneurysm growth. MATERIALS AND METHODS: Velocity profiles were measured for 2 cases of AcomA aneurysms. Realistically shaped models of these aneurysms were constructed, based on CT angiograms. Flow fields and WSS in the models were measured by using particle image velocimetry and LDV. In 1 case, hemodynamic changes were observed in 4 stages of growth over a 27-month period, whereas no development was observed in the other case. RESULTS: The growing model had a smaller and more stagnant recirculation area than that in the nongrowth model. The WSS was markedly reduced in the enlarging region in the growing models, whereas extremely low WSS was not found in the nongrowth model. In addition, a higher WSSG was consistently observed adjacent to the enlarging region during aneurysm growth. CONCLUSIONS: The results indicated that the flow structure of recirculation itself does not necessarily lead to high likelihood of cerebral aneurysm. However, WSSG and WSS were distinctly different between the 2 cases. Higher WSSG was found surrounding the growing region, and extremely low WSS was found at the growing region of the growing cerebral aneurysm.
BACKGROUND AND PURPOSE: Hemodynamic stimulation has been suggested to affect the growth of cerebral aneurysms. The present study examined the effects of intra-aneurysmal hemodynamics on aneurysm growth. MATERIALS AND METHODS: Velocity profiles were measured for 2 cases of AcomA aneurysms. Realistically shaped models of these aneurysms were constructed, based on CT angiograms. Flow fields and WSS in the models were measured by using particle image velocimetry and LDV. In 1 case, hemodynamic changes were observed in 4 stages of growth over a 27-month period, whereas no development was observed in the other case. RESULTS: The growing model had a smaller and more stagnant recirculation area than that in the nongrowth model. The WSS was markedly reduced in the enlarging region in the growing models, whereas extremely low WSS was not found in the nongrowth model. In addition, a higher WSSG was consistently observed adjacent to the enlarging region during aneurysm growth. CONCLUSIONS: The results indicated that the flow structure of recirculation itself does not necessarily lead to high likelihood of cerebral aneurysm. However, WSSG and WSS were distinctly different between the 2 cases. Higher WSSG was found surrounding the growing region, and extremely low WSS was found at the growing region of the growing cerebral aneurysm.
Authors: Paolo Machi; Rafik Ouared; Olivier Brina; Pierre Bouillot; Hasan Yilmaz; Maria I Vargas; Renato Gondar; Philippe Bijlenga; Karl O Lovblad; Zsolt Kulcsár Journal: Clin Neuroradiol Date: 2017-12-05 Impact factor: 3.649
Authors: Melissa C Brindise; Sean Rothenberger; Benjamin Dickerhoff; Susanne Schnell; Michael Markl; David Saloner; Vitaliy L Rayz; Pavlos P Vlachos Journal: J R Soc Interface Date: 2019-09-11 Impact factor: 4.118
Authors: Kamil W Nowicki; Koji Hosaka; Yong He; Peter S McFetridge; Edward W Scott; Brian L Hoh Journal: Hypertension Date: 2014-09-15 Impact factor: 10.190
Authors: Sergey Sindeev; Philipp Georg Arnold; Sergey Frolov; Sascha Prothmann; Dieter Liepsch; Andrea Balasso; Philipp Berg; Stephan Kaczmarz; Jan Stefan Kirschke Journal: PLoS One Date: 2018-01-05 Impact factor: 3.240