Literature DB >> 21984208

Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA.

Yong Gong1, Deyu Zhu, Jingjin Ding, Chuan-Na Dou, Xiaoming Ren, Lichuan Gu, Tao Jiang, Da-Cheng Wang.   

Abstract

Aprataxin is a DNA deadenylase that resolves DNA 5'-AMP termini and reverses abortive DNA ligation. The crystal structures of Schizosaccharomyces pombe aprataxin Hnt3 in its apo form and in complex to dsDNA and dsDNA-AMP reveal how Hnt3 recognizes and processes 5'-adenylated DNA in a structure-specific manner. The bound DNA adopts a 5'-flap conformation that facilitates 5'-AMP access to the active site, where AMP cleavage occurs by a canonical catalytic mechanism.

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Year:  2011        PMID： 21984208     DOI： 10.1038/nsmb.2145

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  16 in total

Review 1.  DNA recognition by Cys2His2 zinc finger proteins.

Authors:  S A Wolfe; L Nekludova; C O Pabo
Journal:  Annu Rev Biophys Biomol Struct       Date:  2000

2.  Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.

Authors:  Charles Brenner
Journal:  Biochemistry       Date:  2002-07-23       Impact factor: 3.162

3.  Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities.

Authors:  Amanda W Kijas; Janelle L Harris; Jonathan M Harris; Martin F Lavin
Journal:  J Biol Chem       Date:  2006-03-16       Impact factor: 5.157

4.  Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Authors:  Gaurang P Deshpande; Jacqueline Hayles; Kwang-Lae Hoe; Dong-Uk Kim; Han-Oh Park; Edgar Hartsuiker
Journal:  DNA Repair (Amst)       Date:  2009-03-04

5.  Actions of aprataxin in multiple DNA repair pathways.

Authors:  Ulrich Rass; Ivan Ahel; Stephen C West
Journal:  J Biol Chem       Date:  2007-02-02       Impact factor: 5.157

6.  Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene.

Authors:  H Date; O Onodera; H Tanaka; K Iwabuchi; K Uekawa; S Igarashi; R Koike; T Hiroi; T Yuasa; Y Awaya; T Sakai; T Takahashi; H Nagatomo; Y Sekijima; I Kawachi; Y Takiyama; M Nishizawa; N Fukuhara; K Saito; S Sugano; S Tsuji
Journal:  Nat Genet       Date:  2001-10       Impact factor: 38.330

Review 7.  Defective DNA repair and neurodegenerative disease.

Authors:  Ulrich Rass; Ivan Ahel; Stephen C West
Journal:  Cell       Date:  2007-09-21       Impact factor: 41.582

8.  Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin.

Authors:  Ulrich Rass; Ivan Ahel; Stephen C West
Journal:  J Biol Chem       Date:  2008-10-03       Impact factor: 5.157

9.  CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.

Authors:  Olivier J Becherel; Burkhard Jakob; Amy L Cherry; Nuri Gueven; Markus Fusser; Amanda W Kijas; Cheng Peng; Sachin Katyal; Peter J McKinnon; Junjie Chen; Bernd Epe; Stephen J Smerdon; Gisela Taucher-Scholz; Martin F Lavin
Journal:  Nucleic Acids Res       Date:  2009-12-14       Impact factor: 16.971

10.  The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.

Authors:  Paula M Clements; Claire Breslin; Emma D Deeks; Philip J Byrd; Limei Ju; Pawel Bieganowski; Charles Brenner; Maria-Céu Moreira; A Malcolm R Taylor; Keith W Caldecott
Journal:  DNA Repair (Amst)       Date:  2004-11-02
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  5 in total

1.  Characterization of 3'-Phosphate RNA Ligase Paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus Highlights DNA and RNA 5'-Phosphate Capping Activity of RtcB3.

Authors:  William P Maughan; Stewart Shuman
Journal:  J Bacteriol       Date:  2015-09-08       Impact factor: 3.490

Review 2.  Repair of double-strand breaks by end joining.

Authors:  Kishore K Chiruvella; Zhuobin Liang; Thomas E Wilson
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-05-01       Impact factor: 10.005

3.  Impact of DNA3'pp5'G capping on repair reactions at DNA 3' ends.

Authors:  Ushati Das; Mathieu Chauleau; Heather Ordonez; Stewart Shuman
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-21       Impact factor: 11.205

4.  DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition.

Authors:  Mathieu Chauleau; Agata Jacewicz; Stewart Shuman
Journal:  Nucleic Acids Res       Date:  2015-05-24       Impact factor: 16.971

5.  The spatial organization of non-homologous end joining: from bridging to end joining.

Authors:  Takashi Ochi; Qian Wu; Tom L Blundell
Journal:  DNA Repair (Amst)       Date:  2014-03-11
  5 in total

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