OBJECTIVES: increased incidence of acute coronary events, high rate of abnormal surrogate markers of atherosclerosis and increased amount of coronary calcium have been described in HIV infected population. To expand knowledge on coronary artery disease (CAD) in HIV patients, cardiac CT scan was performed in asymptomatic subjects with low cardiovascular (CV) risk. METHODS: A cross-sectional study using dual-source CT (MDCT) coronary angiography.was conducted in HIV-infected subjects with the following characteristics: Framingham Risk Score (FRS) ≤10, absence of metabolic syndrome, negative echocardiographic and ECG stress-test. A luminal narrowing exceeding 50% was defined as a clinically significant coronary stenosis. Calcium score was quantified using the Agatston Calcium Score method. RESULTS: Fifty-five subjects were enrolled. Significant coronary stenoses, requiring coronary angiography, were found in 16/55 (29.1%). At multivariate analysis older age was the only variable independently associated with the presence of significant luminal narrowing (p = 0.011). CONCLUSIONS: MDCT showed an unexpected, age-associated high rate of significant coronary stenosis in asymptomatic HIV positive subjects with low CV risk. These findings suggest that aggressive screening programs for coronary artery disease may be appropriate in this population; further studies are recommended to assess the appropriateness of MDCT for this purpose.
OBJECTIVES: increased incidence of acute coronary events, high rate of abnormal surrogate markers of atherosclerosis and increased amount of coronary calcium have been described in HIV infected population. To expand knowledge on coronary artery disease (CAD) in HIVpatients, cardiac CT scan was performed in asymptomatic subjects with low cardiovascular (CV) risk. METHODS: A cross-sectional study using dual-source CT (MDCT) coronary angiography.was conducted in HIV-infected subjects with the following characteristics: Framingham Risk Score (FRS) ≤10, absence of metabolic syndrome, negative echocardiographic and ECG stress-test. A luminal narrowing exceeding 50% was defined as a clinically significant coronary stenosis. Calcium score was quantified using the Agatston Calcium Score method. RESULTS: Fifty-five subjects were enrolled. Significant coronary stenoses, requiring coronary angiography, were found in 16/55 (29.1%). At multivariate analysis older age was the only variable independently associated with the presence of significant luminal narrowing (p = 0.011). CONCLUSIONS: MDCT showed an unexpected, age-associated high rate of significant coronary stenosis in asymptomatic HIV positive subjects with low CV risk. These findings suggest that aggressive screening programs for coronary artery disease may be appropriate in this population; further studies are recommended to assess the appropriateness of MDCT for this purpose.
Authors: T S Metkus; T Brown; M Budoff; L Kingsley; F J Palella; M D Witt; X Li; R T George; L P Jacobson; W S Post Journal: HIV Med Date: 2015-05-13 Impact factor: 3.180
Authors: Jonathan A Hudson; Edith D Majonga; Rashida A Ferrand; Pablo Perel; Shirjel R Alam; Anoop S V Shah Journal: JAMA Date: 2022-09-13 Impact factor: 157.335
Authors: Yalçın Hacıoğlu; Mohit Gupta; Tae Young Choi; Richard T George; Christopher R Deible; Lisa P Jacobson; Mallory D Witt; Frank J Palella; Wendy S Post; Matthew J Budoff Journal: Anadolu Kardiyol Derg Date: 2013-01-30
Authors: Alessandra D'Abramo; Claudia D'Agostino; Alessandra Oliva; Marco Iannetta; Gabriella D'Ettorre; Francesco Vullo; Massimo Mancone; Maria Rosa Ciardi; Claudio Maria Mastroianni; Vincenzo Vullo Journal: ISRN AIDS Date: 2013-12-05