Literature DB >> 21983447

Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

Hong-wang Zhang1, Longhu Zhou, Steven J Coats, Tamara R McBrayer, Phillip M Tharnish, Lavanya Bondada, Mervi Detorio, Sarah A Amichai, Melissa D Johns, Tony Whitaker, Raymond F Schinazi.   

Abstract

Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells. Published by Elsevier Ltd.

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Year:  2011        PMID： 21983447      PMCID： PMC3352596          DOI： 10.1016/j.bmcl.2011.09.034

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  29 in total

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5.  2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.

Authors:  Liesbet Cosyn; Krishnan K Palaniappan; Soo-Kyung Kim; Heng T Duong; Zhan-Guo Gao; Kenneth A Jacobson; Serge Van Calenbergh
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6.  Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors.

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Authors:  Balázs Koscsó; Balázs Csóka; Pál Pacher; György Haskó
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8.  Synthesis and antiviral activity of novel acyclic nucleoside analogues of 5-(1-azido-2-haloethyl)uracils.

Authors:  R Kumar; N Sharma; M Nath; H A Saffran; D L Tyrrell
Journal:  J Med Chem       Date:  2001-11-22       Impact factor: 7.446

9.  3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists.

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Journal:  Bioorg Med Chem Lett       Date:  2007-01-08       Impact factor: 2.823

10.  Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.

Authors:  Anne B Eldrup; Marija Prhavc; Jennifer Brooks; Balkrishen Bhat; Thazha P Prakash; Quanlai Song; Sanjib Bera; Neelima Bhat; Prasad Dande; P Dan Cook; C Frank Bennett; Steven S Carroll; Richard G Ball; Michele Bosserman; Christine Burlein; Lawrence F Colwell; John F Fay; Osvaldo A Flores; Krista Getty; Robert L LaFemina; Joseph Leone; Malcolm MacCoss; Daniel R McMasters; Joanne E Tomassini; Derek Von Langen; Bohdan Wolanski; David B Olsen
Journal:  J Med Chem       Date:  2004-10-07       Impact factor: 7.446
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  1 in total

Review 1.  The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold.

Authors:  Mary K Yates; Katherine L Seley-Radtke
Journal:  Antiviral Res       Date:  2018-12-08       Impact factor: 10.103
  1 in total

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