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Literature DB >> 21982024

Folic acid supplementation in early pregnancy and asthma in children aged 6 years.

Marit P Martinussen¹, Kari R Risnes, Geir W Jacobsen, Michael B Bracken.

Abstract

OBJECTIVE: The objective of the study was to assess whether folic acid intake during the first trimester of pregnancy is related to asthma in the offspring by the age of 6 years. STUDY
DESIGN: This was a prospective cohort study of 1499 women who were followed up from the first trimester of pregnancy. Their children were followed up until they were 6 years old.
RESULTS: Fifty-one percent of the women used folic acid in the month before conception and 88% in the third month of pregnancy. The adjusted odds ratio for asthma per 100 μm increase in the average daily intake of folic acid was 0.98 (95% confidence interval, 0.93-1.04). For categories of daily folate intake, there was no evidence of associations with childhood asthma or evidence of any dose response relation for any time period (all P(trend) > .05).
CONCLUSION: Our results do not support any association of folic acid supplementation in pregnancy and asthma risk in offspring by age 6 years.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2011 PMID： 21982024 PMCID： PMC3246127 DOI： 10.1016/j.ajog.2011.07.033

Source DB: PubMed Journal: Am J Obstet Gynecol ISSN： 0002-9378 Impact factor: 8.661

25 in total

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Authors: John W Hollingsworth; Shuichiro Maruoka; Kathy Boon; Stavros Garantziotis; Zhuowei Li; John Tomfohr; Nathaniel Bailey; Erin N Potts; Gregory Whitehead; David M Brass; David A Schwartz
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3. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention.

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4. Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1,401 US children.

Authors: Kari R Risnes; Kathleen Belanger; William Murk; Michael B Bracken
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Review 5. Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease.

Authors: Graham C Burdge; Karen A Lillycrop
Journal: Annu Rev Nutr Date: 2010-08-21 Impact factor: 11.848

Review 6. Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.

Authors: Anna E Beaudin; Patrick J Stover
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7. Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification.

Authors: Carol Bower; Heather D'Antoine; Fiona J Stanley
Journal: Birth Defects Res A Clin Mol Teratol Date: 2009-04

8. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study.

Authors: Melissa J Whitrow; Vivienne M Moore; Alice R Rumbold; Michael J Davies
Journal: Am J Epidemiol Date: 2009-10-30 Impact factor: 4.897

9. Reduction in neural-tube defects after folic acid fortification in Canada.

Authors: Philippe De Wals; Fassiatou Tairou; Margot I Van Allen; Soo-Hong Uh; R Brian Lowry; Barbara Sibbald; Jane A Evans; Michiel C Van den Hof; Pamela Zimmer; Marian Crowley; Bridget Fernandez; Nora S Lee; Theophile Niyonsenga
Journal: N Engl J Med Date: 2007-07-12 Impact factor: 91.245

10. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring.

Authors: Karen A Lillycrop; Emma S Phillips; Christopher Torrens; Mark A Hanson; Alan A Jackson; Graham C Burdge
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Journal: Am J Respir Crit Care Med Date: 2013-07-01 Impact factor: 21.405

Review 3. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.

Authors: Cynthia K Colapinto; Deborah L O'Connor; Margaret Sampson; Brock Williams; Mark S Tremblay
Journal: J Public Health (Oxf) Date: 2015-07-09 Impact factor: 2.341

Folic acid supplementation in early pregnancy and asthma in children aged 6 years.

Review 1. Quantifying the effect of folic acid.

2. In utero supplementation with methyl donors enhances allergic airway disease in mice.

3. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention.

4. Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1,401 US children.

Review 5. Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease.

Review 6. Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.

7. Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification.

8. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study.

9. Reduction in neural-tube defects after folic acid fortification in Canada.

10. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring.

Review 1. Early life precursors, epigenetics, and the development of food allergy.

Review 2. Folate and asthma.

Review 3. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.

Review 4. Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases.

Review 5. Epigenetic mechanisms and the development of asthma.

6. Association of prenatal folate status with early childhood wheeze and atopic dermatitis.

Review 7. Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis.

Review 8. Diet and asthma: vitamins and methyl donors.

9. Associations between serum folate and vitamin D levels and incident mouse sensitization in adults.

Review 10. Asthma, allergy, and responses to methyl donor supplements and nutrients.