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Literature DB >> 21981955

Etiology and treatment of hypogonadism in adolescents.

Abstract

Adequate functioning at all levels of the hypothalamic-pituitary-gonadal axis is necessary for normal gonadal development and subsequent sex steroid production. Deficiencies at any level of the axis can lead to a hypogonadal state. The causes of hypogonadism are heterogeneous and may involve any level of the reproductive system. This review discusses various causes of hypogonadism, describes the evaluation of hypogonadal states, and outlines treatment options for the induction of puberty in affected adolescents. Whereas some conditions are clearly delineated, the exact etiology and underlying pathogenesis of many disorders is unknown.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2011 PMID： 21981955 PMCID： PMC4102132 DOI： 10.1016/j.pcl.2011.07.009

Source DB: PubMed Journal: Pediatr Clin North Am ISSN： 0031-3955 Impact factor: 3.278

116 in total

1. Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency.

Authors: Marivânia Costa-Santos; Claudio E Kater; Richard J Auchus
Journal: J Clin Endocrinol Metab Date: 2004-01 Impact factor: 5.958

2. Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study.

Authors: Anders Bojesen; Svend Juul; Claus Højbjerg Gravholt
Journal: J Clin Endocrinol Metab Date: 2003-02 Impact factor: 5.958

3. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria?

Authors: F Buzi; R Badolato; C Mazza; S Giliani; Lucia D Notarangelo; G Radetti; A Plebani; Luigi D Notarangelo
Journal: J Clin Endocrinol Metab Date: 2003-07 Impact factor: 5.958

4. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54.

Authors: Nicolas de Roux; Emmanuelle Genin; Jean-Claude Carel; Fumihiko Matsuda; Jean-Louis Chaussain; Edwin Milgrom
Journal: Proc Natl Acad Sci U S A Date: 2003-08-27 Impact factor: 11.205

5. Hypogonadism and pubertal development in Prader-Willi syndrome.

Authors: A Crinò; R Schiaffini; P Ciampalini; S Spera; L Beccaria; F Benzi; L Bosio; A Corrias; L Gargantini; A Salvatoni; G Tonini; G Trifirò; C Livieri
Journal: Eur J Pediatr Date: 2003-02-27 Impact factor: 3.183

6. Reduced ovarian function in long-term survivors of radiation- and chemotherapy-treated childhood cancer.

Authors: Elisabeth C Larsen; Jørn Müller; Kjeld Schmiegelow; Catherine Rechnitzer; Anders Nyboe Andersen
Journal: J Clin Endocrinol Metab Date: 2003-11 Impact factor: 5.958

7. Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function.

Authors: Thomas E Merchant; Tani Williams; Julie M Smith; Susan R Rose; Robert K Danish; George A Burghen; Larry E Kun; Robert H Lustig
Journal: Int J Radiat Oncol Biol Phys Date: 2002-09-01 Impact factor: 7.038

8. PROP-1 gene mutation (R120C) causing combined pituitary hormone deficiencies with variable clinical course in eight siblings of one Jewish Moroccan family.

Authors: L Lazar; G Gat-Yablonski; L Kornreich; A Pertzelan; M Phillip
Journal: Horm Res Date: 2003

9. The radiosensitivity of the human oocyte.

Authors: W H B Wallace; A B Thomson; T W Kelsey
Journal: Hum Reprod Date: 2003-01 Impact factor: 6.918

10. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Authors: I Sadaf Farooqi; Giuseppe Matarese; Graham M Lord; Julia M Keogh; Elizabeth Lawrence; Chizo Agwu; Veronica Sanna; Susan A Jebb; Francesco Perna; Silvia Fontana; Robert I Lechler; Alex M DePaoli; Stephen O'Rahilly
Journal: J Clin Invest Date: 2002-10 Impact factor: 14.808

12 in total

Review 1. Hypogonadism and neurological diseases.

Authors: Abdulaziz Alsemari
Journal: Neurol Sci Date: 2013-01-05 Impact factor: 3.307

2. Clinical, endocrinological, and molecular characterization of Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: a single center experience.

Authors: Sun-Jeong Shin; Yeonah Sul; Ja Hye Kim; Ja Hyang Cho; Gu-Hwan Kim; Jae Hyun Kim; Jin-Ho Choi; Han-Wook Yoo
Journal: Ann Pediatr Endocrinol Metab Date: 2015-03-31

Etiology and treatment of hypogonadism in adolescents.

1. Two prevalent CYP17 mutations and genotype-phenotype correlations in 24 Brazilian patients with 17-hydroxylase deficiency.

2. Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study.

3. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome: time to review diagnostic criteria?

4. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54.

5. Hypogonadism and pubertal development in Prader-Willi syndrome.

6. Reduced ovarian function in long-term survivors of radiation- and chemotherapy-treated childhood cancer.

7. Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function.

8. PROP-1 gene mutation (R120C) causing combined pituitary hormone deficiencies with variable clinical course in eight siblings of one Jewish Moroccan family.

9. The radiosensitivity of the human oocyte.

10. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Review 1. Hypogonadism and neurological diseases.

2. Clinical, endocrinological, and molecular characterization of Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: a single center experience.

3. The association between caffeine intake and testosterone: NHANES 2013-2014.

Review 4. Movement Disorders Associated with Hypogonadism.

Review 5. Delayed and Precocious Puberty: Genetic Underpinnings and Treatments.

6. The female athlete triad.

Review 7. Are sex discordant outcomes in COVID-19 related to sex hormones?

Review 8. Advances in stem cell research for the treatment of primary hypogonadism.

Review 9. Hypogonadotropic hypogonadism revisited.

10. Deletion of FUNDC2 and CMC4 on Chromosome Xq28 Is Sufficient to Cause Hypergonadotropic Hypogonadism in Men.