Literature DB >> 21981465

Ru-catalyzed asymmetric hydrogenation of γ-heteroatom substituted β-keto esters.

Weizheng Fan1, Wanfang Li, Xin Ma, Xiaoming Tao, Xiaoming Li, Ying Yao, Xiaomin Xie, Zhaoguo Zhang.   

Abstract

A series of enantiomerically pure γ-heteroatom substituted β-hydroxy esters were synthesized with high enantioselectivities (up to 99.1% ee) by hydrogenation of γ-heteroatom substituted β-keto esters in the presence of Ru-(S)-SunPhos catalyst. These asymmetric hydrogenations provide key building blocks for a variety of naturally occurring and biologically active compounds.

Entities:  

Year:  2011        PMID： 21981465     DOI： 10.1021/jo201822k

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

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Journal:  J Org Chem       Date:  2012-03-13       Impact factor: 4.354

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3.  Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols.

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Journal:  iScience       Date:  2018-11-09
  3 in total

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