Literature DB >> 21981265

Efficient oxidation of cysteine and glutathione catalyzed by a dinuclear areneruthenium trithiolato anticancer complex.

Federico Giannini1, Georg Süss-Fink, Julien Furrer.   

Abstract

The highly cytotoxic diruthenium complex [(p-MeC(6)H(4)Pr(i))(2)Ru(2)(SC(6)H(4)-p-Me)(3)](+) (1), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of the thiols cysteine and glutathione to give the corresponding disulfides, which may explain its high in vitro anticancer activity.
© 2011 American Chemical Society

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Year:  2011        PMID： 21981265     DOI： 10.1021/ic201941j

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  7 in total

1.  Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(η6-p-MeC6H4Pri)2Ru2(SC6H4-p-X)3]+: synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential.

Authors:  Federico Giannini; Julien Furrer; Anne-Flore Ibao; Georg Süss-Fink; Bruno Therrien; Olivier Zava; Mathurin Baquie; Paul J Dyson; Petr Stěpnička
Journal:  J Biol Inorg Chem       Date:  2012-06-16       Impact factor: 3.358

2.  Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii.

Authors:  Afonso P Basto; Joachim Müller; Riccardo Rubbiani; David Stibal; Federico Giannini; Georg Süss-Fink; Vreni Balmer; Andrew Hemphill; Gilles Gasser; Julien Furrer
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

3.  Interaction of a ruthenium hexacationic prism with amino acids and biological ligands: ESI mass spectrometry and NMR characterisation of the reaction products.

Authors:  Lydia E H Paul; Bruno Therrien; Julien Furrer
Journal:  J Biol Inorg Chem       Date:  2012-07-06       Impact factor: 3.358

4.  Chlorambucil conjugates of dinuclear p-cymene ruthenium trithiolato complexes: synthesis, characterization and cytotoxicity study in vitro and in vivo.

Authors:  David Stíbal; Bruno Therrien; Georg Süss-Fink; Patrycja Nowak-Sliwinska; Paul J Dyson; Eva Čermáková; Martina Řezáčová; Pavel Tomšík
Journal:  J Biol Inorg Chem       Date:  2016-04-04       Impact factor: 3.358

5.  Dinuclear thiolato-bridged arene ruthenium complexes: from reaction conditions and mechanism to synthesis of new complexes.

Authors:  Hedvika Primasová; Silviya Ninova; Mario de Capitani; Jana Daepp; Ulrich Aschauer; Julien Furrer
Journal:  RSC Adv       Date:  2020-11-04       Impact factor: 4.036

6.  Coumarin-Tagged Dinuclear Trithiolato-Bridged Ruthenium(II)⋅Arene Complexes: Photophysical Properties and Antiparasitic Activity.

Authors:  Oksana Desiatkina; Emilia Păunescu; Martin Mösching; Nicoleta Anghel; Ghalia Boubaker; Yosra Amdouni; Andrew Hemphill; Julien Furrer
Journal:  Chembiochem       Date:  2020-06-16       Impact factor: 3.164

7.  Crystal structure of bis-[μ-(4-meth-oxy-phen-yl)methane-thiol-ato-κ(2) S:S]bis-[chlorido-(η(6)-1-isopropyl-4-methyl-benzene)-ruthenium(II)] chloro-form disolvate.

Authors:  David Stíbal; Georg Süss-Fink; Bruno Therrien
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-09-26
  7 in total

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