Literature DB >> 21979321

[T-cells in ANCA-associated vasculitis].

P Lamprecht1, D Kabelitz.   

Abstract

CD4+NKG2D+effector memory T-cell-mediated endothelial cell damage and a Th17 dominated cytokine profile of PR3-specific T-cells may play an important role in the pathogenesis of granulomatosis with polyangiitis (Wegener's). The anti-IL-5 antibody mepolizumab (anti-IL-5) induces remission in Churg-Strauss syndrome.

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Year:  2011        PMID： 21979321     DOI： 10.1007/s00393-011-0780-z

Source DB:  PubMed          Journal:  Z Rheumatol        ISSN： 0340-1855            Impact factor:   1.372


  9 in total

1.  Peripheral blood and granuloma CD4(+)CD28(-) T cells are a major source of interferon-gamma and tumor necrosis factor-alpha in Wegener's granulomatosis.

Authors:  Andras Komocsi; Peter Lamprecht; Elena Csernok; Antje Mueller; Konstanze Holl-Ulrich; Ulrike Seitzer; Frank Moosig; Armin Schnabel; Wolfgang Ludwig Gross
Journal:  Am J Pathol       Date:  2002-05       Impact factor: 4.307

2.  Persistent expansion of CD4+ effector memory T cells in Wegener's granulomatosis.

Authors:  W H Abdulahad; Y M van der Geld; C A Stegeman; C G M Kallenberg
Journal:  Kidney Int       Date:  2006-07-12       Impact factor: 10.612

3.  Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis.

Authors:  Dorin Capraru; Antje Müller; Elena Csernok; Wolfgang L Gross; Konstanze Holl-Ulrich; John Northfield; Paul Klenerman; Karen Herlyn; Julia Holle; Stefan Gottschlich; Jan Voswinkel; Thomas Spies; Ursula Fagin; Wolfram J Jabs; Peter Lamprecht
Journal:  Clin Immunol       Date:  2008-03-04       Impact factor: 3.969

4.  Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.

Authors:  Poh-Yi Gan; Oliver M Steinmetz; Diana S Y Tan; Kim M O'Sullivan; Joshua D Ooi; Yoichiro Iwakura; A Richard Kitching; Stephen R Holdsworth
Journal:  J Am Soc Nephrol       Date:  2010-03-18       Impact factor: 10.121

5.  Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis.

Authors:  Aine C Murphy; Stephen J Lalor; Marina A Lynch; Kingston H G Mills
Journal:  Brain Behav Immun       Date:  2010-02-06       Impact factor: 7.217

6.  Excessive interleukin-15 transpresentation endows NKG2D+CD4+ T cells with innate-like capacity to lyse vascular endothelium in granulomatosis with polyangiitis (Wegener's).

Authors:  Mathilde de Menthon; Marion Lambert; Elsa Guiard; Sara Tognarelli; Boris Bienvenu; Alexandre Karras; Loïc Guillevin; Sophie Caillat-Zucman
Journal:  Arthritis Rheum       Date:  2011-07

7.  Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients.

Authors:  Anna Koskinen; Katriina Vuolteenaho; Riina Nieminen; Teemu Moilanen; Eeva Moilanen
Journal:  Clin Exp Rheumatol       Date:  2011-02-23       Impact factor: 4.473

8.  Lower numbers of FoxP3 and CCR4 co-expressing cells in an elevated subpopulation of CD4+CD25high regulatory T cells from Wegener's granulomatosis.

Authors:  Sebastian Klapa; Antje Mueller; Elena Csernok; Ursula Fagin; Paul Klenerman; Konstanze Holl-Ulrich; Wolfgang L Gross; Peter Lamprecht
Journal:  Clin Exp Rheumatol       Date:  2010 Jan-Feb       Impact factor: 4.473

Review 9.  T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells?

Authors:  Benjamin Wilde; Marielle Thewissen; Jan Damoiseaux; Pieter van Paassen; Oliver Witzke; Jan Willem Cohen Tervaert
Journal:  Arthritis Res Ther       Date:  2010-02-24       Impact factor: 5.156
  9 in total

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