Literature DB >> 21979109

Brief report: Platelet-poor plasma serotonin in autism.

George M Anderson1, Margaret E Hertzig, P A McBride.   

Abstract

Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet's handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (± SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet's handling of 5-HT.

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Year:  2012        PMID： 21979109     DOI： 10.1007/s10803-011-1371-1

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  36 in total

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Authors:  R B Minderaa; G M Anderson; F R Volkmar; G W Akkerhuis; D J Cohen
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Journal:  Neuropsychobiology       Date:  1988       Impact factor: 2.328

4.  Steady-state model for plasma free and platelet serotonin in man.

Authors:  G M Anderson; J M Stevenson; D J Cohen
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5.  Free serotonin in plasma: autistic children and their first-degree relatives.

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9.  Serotonin and dopamine transporter binding in children with autism determined by SPECT.

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Review 9.  Blood platelet research in autism spectrum disorders: In search of biomarkers.

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