| Literature DB >> 21978970 |
Hong-Bing Xiang1, Cheng Liu, Qing-Qing Guo, Rong-Chun Li, Da-Wei Ye.
Abstract
Deep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) had usually been reported to improve the symptoms of advanced Parkinson's disease. Previous studies showed that neurons in the PPTg involved in the control of the sympathetic outflow to the kidneys. Our recent studies using transneuronal labeling pseudorabies virus (PRV)-614 supported the sympathetic nature of the caudal PPTg. We propose a hypothesis that deep brain stimulation of the PPTg may influence renal function by serotonergic and catecholaminergic pathways. Because PRV-614/tryptophan hydroxylase and PRV-614/tyrosine hydroxylase double-labeled neurons in the compact parts of PPTg (cpPPTg) were not detected, deep brain stimulation of the cpPPTg might not influence renal function.Entities:
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Year: 2011 PMID： 21978970 DOI： 10.1016/j.mehy.2011.09.022
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538