Literature DB >> 21978675

Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors.

Gopi Kumar Mittapalli1, Andrew Jackson, Fang Zhao, Haekyung Lee, Stephine Chow, Jeffrey McKelvy, Flossie Wong-Staal, James E Macdonald.   

Abstract

Novel, highly potent small molecule HCV entry inhibitors are reported. The SAR exploration of a hit molecule identified from screening of a compound library led to the identification of highly potent compounds with IC(50) values of <5 nM in the tissue culture HCV infectious assay.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21978675     DOI： 10.1016/j.bmcl.2011.09.019

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

Authors:  Shanshan He; Kelin Li; Billy Lin; Zongyi Hu; Jingbo Xiao; Xin Hu; Amy Q Wang; Xin Xu; Marc Ferrer; Noel Southall; Wei Zheng; Jeffrey Aubé; Frank J Schoenen; Juan J Marugan; T Jake Liang; Kevin J Frankowski
Journal:  J Med Chem       Date:  2017-07-13       Impact factor: 7.446

2.  Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Authors:  Chris Dockendorff; Patrick W Faloon; Jun Pu; Miao Yu; Stephen Johnston; Melissa Bennion; Marsha Penman; Thomas J F Nieland; Sivaraman Dandapani; José R Perez; Benito Munoz; Michelle A Palmer; Stuart L Schreiber; Monty Krieger
Journal:  Bioorg Med Chem Lett       Date:  2015-04-01       Impact factor: 2.823

Review 3.  Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization.

Authors:  Koen Vercauteren; Ahmed Atef Mesalam; Geert Leroux-Roels; Philip Meuleman
Journal:  World J Gastroenterol       Date:  2014-11-21       Impact factor: 5.742

4.  Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Authors:  Chris Dockendorff; Patrick W Faloon; Andrew Germain; Miao Yu; Willmen Youngsaye; Partha P Nag; Melissa Bennion; Marsha Penman; Thomas J F Nieland; Sivaraman Dandapani; José R Perez; Benito Munoz; Michelle A Palmer; Stuart L Schreiber; Monty Krieger
Journal:  Bioorg Med Chem Lett       Date:  2015-04-11       Impact factor: 2.823

5.  Chemoselective O-Alkylation of 4-(Trifluoromethyl)pyrimidin-2(1H)-ones Using 4-(Iodomethyl)pyrimidines.

Authors:  Mateus Mittersteiner; Genilson S Pereira; Ludger A Wessjohann; Helio G Bonacorso; Marcos A P Martins; Nilo Zanatta
Journal:  ACS Omega       Date:  2022-05-24

Review 6.  Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives.

Authors:  Sulong Xiao; Zhenyu Tian; Yufei Wang; Longlong Si; Lihe Zhang; Demin Zhou
Journal:  Med Res Rev       Date:  2018-01-19       Impact factor: 12.944

7.  High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.

Authors:  Michael J Wichroski; Jie Fang; Betsy J Eggers; Ronald E Rose; Charles E Mazzucco; Kevin A Pokornowski; Carl J Baldick; Monique N Anthony; Craig J Dowling; Lauren E Barber; John E Leet; Brett R Beno; Samuel W Gerritz; Michele L Agler; Mark I Cockett; Daniel J Tenney
Journal:  PLoS One       Date:  2012-08-06       Impact factor: 3.240

Review 8.  Host-Targeting Agents to Prevent and Cure Hepatitis C Virus Infection.

Authors:  Mirjam B Zeisel; Emilie Crouchet; Thomas F Baumert; Catherine Schuster
Journal:  Viruses       Date:  2015-11-02       Impact factor: 5.048
  8 in total

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