OBJECTIVE: To determine whether patients with cirrhosis and depressive symptoms have a different neuropsychological cognitive profile from patients with cirrhosis without depressive symptoms in order to show that cirrhosis may not be the only cause for cognitive decline in patients with cirrhosis. METHOD: Adult outpatients with a diagnosis of cirrhosis based on histologic findings and clinical characteristics, who did not have clinically overt hepatic encephalopathy and who were being treated in the advanced liver disease and liver transplant clinics, were recruited for the study from May 2003 to May 2006. Patients underwent neuropsychological testing and evaluation for depression using the Beck Depression Inventory-II (BDI-II). Age-adjusted standard neuropsychological domain scores were compared between depressed (BDI-II score ≥ 14) and nondepressed (BDI-II score < 14) patients. RESULTS: Seventy-five subjects were included in the study. The 23 patients with depression were similar to the 52 nondepressed patients in level of education, age, and race; the laboratory parameters of international normalized ratio, bilirubin, creatinine, and albumin concentration; and Model for End-Stage Liver Disease scores. There was a higher percentage of women in the depressed group than in the nondepressed group, with a trend toward significance (52% vs 29%; P = .07). No etiology of liver disease was associated with depression. In linear regression analyses, decreases in cognitive function were associated with higher BDI-II scores for the domains of working memory (P = .026), with a trend toward significance for visual-perception (P = .056). Approximately 7% of the variability in working memory score was predicted using the BDI score. CONCLUSIONS: Depressive symptoms are associated with worsened cognitive function in cirrhosis.
OBJECTIVE: To determine whether patients with cirrhosis and depressive symptoms have a different neuropsychological cognitive profile from patients with cirrhosis without depressive symptoms in order to show that cirrhosis may not be the only cause for cognitive decline in patients with cirrhosis. METHOD: Adult outpatients with a diagnosis of cirrhosis based on histologic findings and clinical characteristics, who did not have clinically overt hepatic encephalopathy and who were being treated in the advanced liver disease and liver transplant clinics, were recruited for the study from May 2003 to May 2006. Patients underwent neuropsychological testing and evaluation for depression using the Beck Depression Inventory-II (BDI-II). Age-adjusted standard neuropsychological domain scores were compared between depressed (BDI-II score ≥ 14) and nondepressed (BDI-II score < 14) patients. RESULTS: Seventy-five subjects were included in the study. The 23 patients with depression were similar to the 52 nondepressed patients in level of education, age, and race; the laboratory parameters of international normalized ratio, bilirubin, creatinine, and albumin concentration; and Model for End-Stage Liver Disease scores. There was a higher percentage of women in the depressed group than in the nondepressed group, with a trend toward significance (52% vs 29%; P = .07). No etiology of liver disease was associated with depression. In linear regression analyses, decreases in cognitive function were associated with higher BDI-II scores for the domains of working memory (P = .026), with a trend toward significance for visual-perception (P = .056). Approximately 7% of the variability in working memory score was predicted using the BDI score. CONCLUSIONS:Depressive symptoms are associated with worsened cognitive function in cirrhosis.
Authors: Daniel M Forton; Howard C Thomas; Christine A Murphy; Joanna M Allsop; Graham R Foster; Janice Main; Keith A Wesnes; Simon D Taylor-Robinson Journal: Hepatology Date: 2002-02 Impact factor: 17.425
Authors: Daniel M Forton; Joanna M Allsop; I Jane Cox; Gavin Hamilton; Keith Wesnes; Howard C Thomas; Simon D Taylor-Robinson Journal: AIDS Date: 2005-10 Impact factor: 4.177
Authors: Herbert L Bonkovsky; Kristin K Snow; Peter F Malet; Carla Back-Madruga; Robert J Fontana; Richard K Sterling; Clark C Kulig; Adrian M Di Bisceglie; Timothy R Morgan; Jules L Dienstag; Marc G Ghany; David R Gretch Journal: J Hepatol Date: 2006-11-27 Impact factor: 25.083
Authors: Juan Fernando Gallegos-Orozco; Ana Paula Fuentes; Juan Gerardo Argueta; Christian Pérez-Pruna; Carlos Hinojosa-Becerril; Ma Sara Sixtos-Alonso; Socorro Cruz-Castellanos; Gabriela Gutiérrez-Reyes; Marco Antonio Olivera-Martínez; Ma Concepción Gutiérrez-Ruiz; David Kershenobich Journal: Arch Med Res Date: 2003 Mar-Apr Impact factor: 2.235
Authors: Amy A Dan; Lisa M Martin; Cathy Crone; Janus P Ong; Denise W Farmer; Thomas Wise; Sean C Robbins; Zobair M Younossi Journal: J Hepatol Date: 2005-12-27 Impact factor: 25.083
Authors: Peter Ferenci; Alan Lockwood; Kevin Mullen; Ralph Tarter; Karin Weissenborn; Andres T Blei Journal: Hepatology Date: 2002-03 Impact factor: 17.425
Authors: Jasmohan S Bajaj; Leroy R Thacker; Douglas M Heuman; Richard K Sterling; R Todd Stravitz; Arun J Sanyal; Velimir Luketic; Michael Fuchs; Ho Chong S Gilles; James B Wade Journal: Liver Transpl Date: 2012-10 Impact factor: 5.799