Sir,A previous publication on insulin resistance, fibrinogen, homocysteine, leptin, and C-reactive protein is very interesting.[1] Basoglu et al. reported that “This study demonstrated that obese OSASpatients may have an increased rate of metabolic syndrome and higher levels of serum lipids, fasting glucose, IR, leptin, fibrinogen, and hsCRP than obese subjects without sleep apnea.[1] ”There are few questions about this report. First, the use of simple two questions for classification of alcohol consumption and smoking might have the problem of reliability. There should be some testing on the reliability. Second, although Basoglu et al. reported the CV of some tests, they did not report for all. The measurement of serum concentrations of glucose, triglyceride, total and HDL-cholesterol can be performed by several enzymatic techniques. For sure, each technique has its specific limitation and interference.