Literature DB >> 21976225

Development of a human-murine chimeric immunoglobulin M for use in the serological detection of human alphavirus antibodies.

Brett A Thibodeaux1, Nathan M Liss, Amanda N Panella, John T Roehrig.   

Abstract

Diagnosis of human alphaviral infections relies on serological techniques, such as the immunoglobulin M antibody capture-enzyme-linked immunosorbent assay (MAC-ELISA). We have humanized the alphavirus broadly cross-reactive murine monoclonal antibody 1A4B-6 to create a reagent capable of replacing human positive sera in the MAC-ELISA for diagnosis of human alphaviral infections.

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Year:  2011        PMID： 21976225      PMCID： PMC3232697          DOI： 10.1128/CVI.05269-11

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  4 in total

1.  Development of human-murine chimeric immunoglobulin G for use in the serological detection of human flavivirus and alphavirus antibodies.

Authors:  Brett A Thibodeaux; Amanda N Panella; John T Roehrig
Journal:  Clin Vaccine Immunol       Date:  2010-08-25

2.  Identification of monoclonal antibodies capable of differentiating antigenic varieties of eastern equine encephalitis viruses.

Authors:  J T Roehrig; A R Hunt; G J Chang; B Sheik; R A Bolin; T F Tsai; D W Trent
Journal:  Am J Trop Med Hyg       Date:  1990-04       Impact factor: 2.345

3.  Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections.

Authors:  D A Martin; D A Muth; T Brown; A J Johnson; N Karabatsos; J T Roehrig
Journal:  J Clin Microbiol       Date:  2000-05       Impact factor: 5.948

4.  Development of a human-murine chimeric immunoglobulin M antibody for use in the serological detection of human flavivirus antibodies.

Authors:  Brett A Thibodeaux; John T Roehrig
Journal:  Clin Vaccine Immunol       Date:  2009-03-18
  4 in total
  2 in total

1.  A humanized IgG but not IgM antibody is effective in prophylaxis and therapy of yellow fever infection in an AG129/17D-204 peripheral challenge mouse model.

Authors:  Brett A Thibodeaux; Nina C Garbino; Nathan M Liss; Joseph Piper; Jacob J Schlesinger; Carol D Blair; John T Roehrig
Journal:  Antiviral Res       Date:  2012-02-15       Impact factor: 5.970

2.  Development of an algorithm for production of inactivated arbovirus antigens in cell culture.

Authors:  C H Goodman; B J Russell; J O Velez; J J Laven; W L Nicholson; D A Bagarozzi; J L Moon; K Bedi; B W Johnson
Journal:  J Virol Methods       Date:  2014-08-04       Impact factor: 2.014
  2 in total

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