Synthesis of d-f coordination polymer nanoparticles and their application in phosphorescence and magnetic resonance imaging.

Magneto-phosphorescent d-f coordination polymer nanoparticles (f-CPPs) were conveniently synthesized by phosphorescent carboxyl-functionalized iridium complexes as building blocks and magnetic Gd(III) ions as metallic nodes. They reveal uniform hollow spheres with an average diameter of around 60 nm and wall thickness of about 10 nm. Water soluble f-CPPs were obtained by polyvinylpyrolidone modification (denoted as f-CPPs@PVP), which had an intense red phosphorescence, moderate longitudinal relaxivity (r(1)) and low cytotoxicity. Furthermore, inductively coupled plasma atomic emission spectroscopy (ICP-AES) and confocal laser scanning microscopy (CLSM) confirmed f-CPPs@PVP could be taken up by living cells effectively. Therefore, they should be a novel nano-bioprobe for the multimodal imaging of cancer cells.