AIM: Decreased activity of the mitochondrial electron transport chain (ETC) has been implicated in the pathogenesis of Parkinson's disease (PD). This model would most likely predict a decrease in the rate of cerebral oxygen consumption (CMRO(2)). To test this hypothesis, we compared CMRO(2) and cerebral blood flow (CBF) PET scans from PD patients and healthy controls. MATERIALS AND METHODS: Nine early-stage PD patients and 15 healthy age-matched controls underwent PET scans for quantitative mapping of CMRO(2) and CBF. Between-group differences were evaluated for absolute data and intensity-normalized values. RESULTS: No group differences were detected in regional magnitudes of CMRO(2) or CBF. Upon normalization using the reference cluster method, significant relative CMRO(2) decreases were evident in widespread prefrontal, parieto-occipital, and lateral temporal regions. Sensory-motor and subcortical regions, brainstem, and the cerebellum were spared. A similar pattern was evident in normalized CBF data, as described previously. CONCLUSION: While the data did not reveal substantially altered absolute CMRO(2) in brain of PD patients, employing data-driven intensity normalization revealed widespread relative CMRO(2) decreases in cerebral cortex. The detected pattern was very similar to that reported in earlier CBF and CMRglc studies of PD, and in the CBF images from the same subjects. Thus, the present results are consistent with the occurrence of parallel declines in CMRO(2), CBF, and CMRglc in spatially contiguous cortical regions in early PD, and support the hypothesis that ETC dysfunction could be a primary pathogenic mechanism in early PD.
AIM: Decreased activity of the mitochondrial electron transport chain (ETC) has been implicated in the pathogenesis of Parkinson's disease (PD). This model would most likely predict a decrease in the rate of cerebral oxygen consumption (CMRO(2)). To test this hypothesis, we compared CMRO(2) and cerebral blood flow (CBF) PET scans from PDpatients and healthy controls. MATERIALS AND METHODS: Nine early-stage PDpatients and 15 healthy age-matched controls underwent PET scans for quantitative mapping of CMRO(2) and CBF. Between-group differences were evaluated for absolute data and intensity-normalized values. RESULTS: No group differences were detected in regional magnitudes of CMRO(2) or CBF. Upon normalization using the reference cluster method, significant relative CMRO(2) decreases were evident in widespread prefrontal, parieto-occipital, and lateral temporal regions. Sensory-motor and subcortical regions, brainstem, and the cerebellum were spared. A similar pattern was evident in normalized CBF data, as described previously. CONCLUSION: While the data did not reveal substantially altered absolute CMRO(2) in brain of PDpatients, employing data-driven intensity normalization revealed widespread relative CMRO(2) decreases in cerebral cortex. The detected pattern was very similar to that reported in earlier CBF and CMRglc studies of PD, and in the CBF images from the same subjects. Thus, the present results are consistent with the occurrence of parallel declines in CMRO(2), CBF, and CMRglc in spatially contiguous cortical regions in early PD, and support the hypothesis that ETC dysfunction could be a primary pathogenic mechanism in early PD.
Authors: You-hai Xu; Kui Xu; Ying Sun; Benjamin Liou; Brian Quinn; Rong-hua Li; Ling Xue; Wujuan Zhang; Kenneth D R Setchell; David Witte; Gregory A Grabowski Journal: Hum Mol Genet Date: 2014-03-05 Impact factor: 6.150
Authors: Juergen Dukart; Robert Perneczky; Stefan Förster; Henryk Barthel; Janine Diehl-Schmid; Bogdan Draganski; Hellmuth Obrig; Emiliano Santarnecchi; Alexander Drzezga; Andreas Fellgiebel; Richard Frackowiak; Alexander Kurz; Karsten Müller; Osama Sabri; Matthias L Schroeter; Igor Yakushev Journal: PLoS One Date: 2013-02-25 Impact factor: 3.240
Authors: Kristian N Mortensen; Albert Gjedde; Garth J Thompson; Peter Herman; Maxime J Parent; Douglas L Rothman; Ron Kupers; Maurice Ptito; Johan Stender; Steven Laureys; Valentin Riedl; Michael T Alkire; Fahmeed Hyder Journal: Neural Plast Date: 2018-06-12 Impact factor: 3.599