| Literature DB >> 21974949 |
Elena Koltun1, Steven Richards, Vicky Chan, Jason Nachtigall, Hongwang Du, Kevin Noson, Adam Galan, Naing Aay, Art Hanel, Amanda Harrison, Jeff Zhang, Kwang-Ai Won, Danny Tam, Fawn Qian, Tao Wang, Patricia Finn, Kathleen Ogilvie, Jon Rosen, Raju Mohan, Christopher Larson, Peter Lamb, John Nuss, Patrick Kearney.
Abstract
A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.Entities:
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Year: 2011 PMID： 21974949 DOI： 10.1016/j.bmcl.2011.09.037
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823